Anti-DPP8 antibody produced in rabbit

DPP8 (dipeptidyl-peptidase 8) is a dipeptidyl aminopeptidase, which cleaves in a post-proline manner, and is a homolog of DPPIV and FAP (fibroblast activation protein). This gene is localized to human chromosome 15q22, and codes for a protein of 882 amino acids. This gene has a ubiquitous expression pattern. It is localized to the cytoplasm and has a molecular weight of 100kDa. It lacks N- and O-glycosylation sites and transmembrane region. It belongs to the DPPIV gene family.

Dipeptidyl peptidase 8 recombinant protein epitope signature tag (PrEST)

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

DPP8 (dipeptidyl-peptidase 8) is thought to have immunological roles, with involvement in lung allergic responses and bowel inflammatory disorders. It is up-regulated in human meningiomas, and its mRNa is found in chronic lymphocytic leukemia. It acts as a survival factor in Ewing sarcoma family of tumors. It also cleaves neuropeptide Y, glucagon-like peptide-2 and peptide YY. It is involved in the pathogenesis of liver disease, where it is implicated in lymphocyte activation and apoptosis. In atherosclerosis, this protein has a high expression in macrophage-dominant regions of plaque. As macrophages play a prominent role in atherosclerosis pathogenesis, this protein might be involved in the same.

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Corresponding Antigen APREST71650

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

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