Skip to Content
MilliporeSigma
Get 22% off for Pi Day through March 31.Save Now

Key Documents

View All Documentation

Skip To

30970

Sodium deoxycholate

BioXtra, ≥98.0% (dry matter, NT)

Synonym(s):

3α,12α-Dihydroxy-5β-cholanic acid sodium salt, 7-Deoxycholic acid sodium salt, Desoxycholic acid sodium salt

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View
Pack SizeSKUAvailabilityPrice
25 g

Available to ship TODAYfromMILWAUKEE

$67.80
100 g

Available to ship TODAYfromMILWAUKEE

$185.00
500 g

Available to ship TODAYfromMILWAUKEE

$731.00

About This Item

Empirical Formula (Hill Notation):
C24H39NaO4
CAS Number:
302-95-4
Molecular Weight:
414.55
UNSPSC Code:
12161900
NACRES:
NA.21
PubChem Substance ID:
57648497
EC Number:
206-132-7
Beilstein/REAXYS Number:
3581950
MDL number:
MFCD00064139

$67.80

Available to ship TODAYDetails

​
Request a Bulk Order
​
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

biological source

ox bile

Quality Level

300

description

anionic

product line

BioXtra

assay

≥98.0% (dry matter, NT)

form

powder

optical activity

[α]20/D +44±2°, c = 2% in H2O

mol wt

micellar avg mol wt 1200-5000

aggregation number

3-12

technique(s)

DNA purification: suitable, RNA purification: suitable, electrophoresis: suitable

Looking for similar products? Visit Product Comparison Guide

Related Categories

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item
D67501.06504S1827
Sodium deoxycholate BioXtra, ≥98.0% (dry matter, NT)

Sigma-Aldrich

30970

Sodium deoxycholate

Sodium deoxycholate ≥97% (titration)

Sigma-Aldrich

D6750

Sodium deoxycholate

Sodium deoxycholate Bile salt and ionic detergent. Supplement. For the isolation and classification of gram-negative bacteria

Millipore

1.06504

Sodium deoxycholate

Sodium deoxycholate

SAFC

S1827

Sodium deoxycholate

form

powder

form

powder

form

solid

form

powder

technique(s)

DNA purification: suitable, electrophoresis: suitable, RNA purification: suitable

technique(s)

-

technique(s)

-

technique(s)

-

assay

≥98.0% (dry matter, NT)

assay

≥97% (titration)

assay

-

assay

≥98% (HPLC)

aggregation number

3-12

aggregation number

3-12

aggregation number

-

aggregation number

3-12

biological source

ox bile

biological source

-

biological source

-

biological source

animal

CMC

2-6 mM (20-25°C)

CMC

2-6 mM (20-25°C)

CMC

-

CMC

2-6 mM (20-25°C)

General description

Sodium Deoxycholate, a bile acid derivative, is a crucial component in biochemical and cell biology research. This water-soluble detergent is widely used in protein-related experiments, including cell lysates and liposome preparation. It aids in membrane protein extraction, lipid compound extraction, and cell nucleus separation. Sodium Deoxycholate is also applied in cholesterol flocculation tests and affinity chromatography for column elution or regeneration. It is commonly used in microbiology for cell lysing, especially because it can be removed from the solution via dialysis.

Sodium Deoxycholate is also utilized in eluting buffers for affinity chromatography and plays a crucial role in DNA and RNA extraction from cells and tissues in molecular biology applications. Additionally, it is used as a catalyst in the preparation of protein extracts for immunoblotting and immunoprecipitation of radiolabeled proteins.

Application

Sodium deoxycholate has been used for preparation of protein extracts for immunoblotting[1] and immunoprecipitation of radiolabeled proteins.[2]

Biochem/physiol Actions

Sodium deoxycholate is a bile salt that stimulates the apical to basolateral accumulation of epirubicin in Caco-2 cells[3] as well as increased serosal absorption of epirubicin in the rat jejunum and ileum.[4] Sodium deoxycholate dissociates histones II from DNA as well as causes lysis of the viral membrane.[5]

Features and Benefits

  • Suitable for Cell Biology and Biochemical Research
  • Can be used in Electrophoresis, DNA and RNA purification
  • Tested to confirm low levels of heavy metal contamination, ensuring suitability for various applications.
  • High purity product for research applications

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research
For additional information on our range of Biochemicals, please complete this form.

comparable product

Product No.
Description
Pricing

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
BCCP2489
BCCN6992
BCCN6991
BCCN5723
BCCN2985

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

G Ramadori et al.
The Journal of experimental medicine, 162(3), 930-942 (1985-09-01)
During the acute phase response to tissue injury or inflammation, the concentration of several plasma proteins change. Previous work (29-34) suggested a role for interleukin 1 (IL-1) in the acute phase response. The availability of recombinant-generated mouse IL-1 prompted a
Y L Lo et al.
Biochemical pharmacology, 59(6), 665-672 (2000-02-25)
The effects of sodium deoxycholate (Deo-Na), a bile salt, and sodium caprate (Cap-Na), a fatty acid, on the transport of epirubicin were investigated in both the human colon adenocarcinoma (Caco-2) cell line and the everted gut sacs of the rat
Selective dissociation of histones from chromatin by sodium deoxycholate.
J E Smart et al.
Journal of molecular biology, 58(3), 651-659 (1971-06-28)
A Helenius et al.
Biochimica et biophysica acta, 436(2), 319-334 (1976-06-17)
The effects of increasing concentrations of sodium deoxycholate on Semliki Forest have been studied. Sodium deoxycholate begins to bind to the virus at less than 0.1 mM free equilibrium concentration and causes lysis of the viral membrane at 0.9 +/-
Gang Chen et al.
Autophagy, 8(11), 1577-1589 (2012-08-10)
Ethanol is a neuroteratogen and neurodegeneration is the most devastating consequence of developmental exposure to ethanol. The mechanisms underlying ethanol-induced neurodegeneration are complex. Ethanol exposure produces reactive oxygen species (ROS) which cause oxidative stress in the brain. We hypothesized that
View All Related Papers

Articles

Simple Digestion Protocol for Proteomics Sample Prep

Rapid trypsin digest kit yields reliable results in less than 2 hours for mass spectrometry analysis.

Protocols

LPL Activity Assay Protocol

Lipoprotein lipase (LPL) hydrolyzes triglycerides associated with VLDL.

Global Trade Item Number

SKUGTIN
30970-500G04061826676257
30970-25G04061835541249
30970-100G04061826676233

Questions

1–2 of 2 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service