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F9397

Flutamide

Non-steroidal anti-androgen drug

Synonym(s):

2-Methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide

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1 g

Available to ship TODAYfromMILWAUKEE

$53.30
5 g

Available to ship TODAYfromMILWAUKEE

$182.00

About This Item

Empirical Formula (Hill Notation):
C11H11F3N2O3
CAS Number:
13311-84-7
Molecular Weight:
276.21
NACRES:
NA.77
PubChem Substance ID:
24278446
UNSPSC Code:
51111800
EC Number:
236-341-9
MDL number:
MFCD00072009
Quality level:
100

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Product Name

Flutamide,

Quality Level

100

originator

Schering Plough

SMILES string

CC(C)C(=O)Nc1ccc(c(c1)C(F)(F)F)[N+]([O-])=O

InChI

1S/C11H11F3N2O3/c1-6(2)10(17)15-7-3-4-9(16(18)19)8(5-7)11(12,13)14/h3-6H,1-2H3,(H,15,17)

InChI key

MKXKFYHWDHIYRV-UHFFFAOYSA-N

Gene Information

human ... AR(367)
mouse ... Ar(11835)
rat ... Ar(24208)

Application

Flutamide has been used to effect of testosterone on Glial cell-derived neurotrophic factor (Gdnf) mRNA production in vitro.[1] It has also been used to study the effects of flutamide on anogenital distance and nipple retention.

Biochem/physiol Actions

Flutamide is a non-steroidal anti-androgen drug. It consists of a nitroaromatic structure. Flutamide is a potent competitor of testosterone and dihydrotestosterone receptors. It is a potent hepatotoxin.

Features and Benefits

This compound was developed by Schering Plough. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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1 of 1

This Item
H4166N8534SML1626
Flutamide

Sigma-Aldrich

F9397

Flutamide

Hydroxyflutamide ≥98% (HPLC)

Sigma-Aldrich

H4166

Hydroxyflutamide

Nilutamide solid

Sigma-Aldrich

N8534

Nilutamide

TFCA ≥98% (HPLC)

Sigma-Aldrich

SML1626

TFCA

Quality Level

100

Quality Level

100

Quality Level

200

Quality Level

100

originator

Schering Plough

originator

Schering Plough

originator

Sanofi Aventis

originator

-

Gene Information

human ... AR(367)
mouse ... Ar(11835)
rat ... Ar(24208)

Gene Information

-

Gene Information

human ... AR(367)

Gene Information

-

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Warning

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 2 - Carc. 2 - Repr. 2 - STOT RE 2

target_organs

Liver

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
MKDB0485
MKCW9761
MKCT5085
MKCR8700
MKCP9859

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Related Content

Product Information Sheet - F9397

Product Information Sheet

Flutamide-induced hepatotoxicity: ethical and scientific issues
Giorgetti R, et al.
European Review for Medical and Pharmacological Sciences, 21(1 Suppl), 69-77 (2017)
N A Spry et al.
Prostate cancer and prostatic diseases, 16(1), 67-72 (2012-08-22)
To examine changes to whole body and regional lean mass (LM) and fat mass (FM) over 33 months of intermittent androgen suppression therapy (IAST). Phase II cohort study of 72 prostate cancer patients without metastatic bone disease. Patients received flutamide
Shuchen Gu et al.
Cellular signalling, 25(1), 66-73 (2013-01-15)
Actin cytoskeleton reorganization initiated by testosterone conjugates through activation of membrane androgen receptors (mAR) has recently been reported in colon tumor cells. This mAR-induced actin reorganization was recognized as a critical initial event, controlling apoptosis and inhibiting cell migration. The
View All Related Papers

Global Trade Item Number

SKUGTIN
F9397-1G04061833621592
F9397-5G04061833621608

Questions

  1. How Can I prepare 1nM solution of flutamide? flutamide dissolves in ethanol? AFTER DISSOLVING flutamide IN ETHANOL , WHATS the storage conditions and useful life?

    1 answer

    1. Flutamide is soluble in ethanol (50 mg/ml) with heat as needed, yielding a clear to hazy, yellow to yellow-green solution. It is also soluble in acetone, ethyl acetate, methanol, chloroform, and ether.

      The molecular weight of flutamide is 276.21, and this value can be used to calculate the amount needed to make a 1nM solution in the desired volume:
      https://www.sigmaaldrich.com/support/calculators-and-apps/mass-molarity-calculator

      Using freshly made solutions whenever possible is always recommended, but storing them at -20°C in non-diluted aliquots should maintain their stability for at least one month.

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