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A76109

Sigma-Aldrich

3-Amino-1-propanesulfonic acid

97%

Synonym(s):

3APS, Homotaurine, Tramiprosate

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1 G
$46.64
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1 G
$46.64
5 G
$123.50

About This Item

Linear Formula:
H2N(CH2)3SO3H
CAS Number:
Molecular Weight:
139.17
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22

$46.64

List Price$49.10Save 5%

In StockDetails


Request a Bulk Order

Quality Level

assay

97%

form

solid

mp

293 °C (dec.) (lit.)

SMILES string

NCCCS(O)(=O)=O

InChI

1S/C3H9NO3S/c4-2-1-3-8(5,6)7/h1-4H2,(H,5,6,7)

InChI key

SNKZJIOFVMKAOJ-UHFFFAOYSA-N

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Application

Important gabamimetic agent-evokes neurological responses similar to those elicited by γ-aminobutyric acid (GABA).[1][2][3][4]

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


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S Gauthier et al.
The journal of nutrition, health & aging, 13(6), 550-557 (2009-06-19)
The efficacy, safety and disease-modification of tramiprosate (homotaurine)were investigated in a recently completed large-scale Phase III clinical study in patients with mild to moderate Alzheimer's disease (AD), the Alphase study. Disease-modification was assessed using longitudinal volumetric MRI (vMRI) measurements of
D Saumier et al.
The journal of nutrition, health & aging, 13(9), 808-812 (2009-10-09)
Tramiprosate (homotaurine, ALZHEMEDTM) was recently investigated for its efficacy, safety and disease-modification effects in a Phase III clinical study in mild to moderate Alzheimer's disease (AD) patients (the Alphase study). The primary cognitive endpoint measure of that study was the
J Y Wu et al.
Journal of biomedical science, 8(1), 96-103 (2001-02-15)
Acamprosate (AC), N-acetyl-homotaurine, has recently been introduced for treating alcohol craving and reducing relapses in weaned alcoholics. AC may exert its action through the taurine system rather than the glutamatergic or GABAergic system. This conclusion is based on the observations
R Nageswara Rao et al.
Journal of pharmaceutical and biomedical analysis, 55(2), 282-287 (2011-02-18)
Alzheimer disease (AD) is characterized pathologically by extracellular amyloid deposits composed of amyloid β (Aβ) protein. A simple and rapid method using HPLC with fluorescence detector was developed and validated for determination of tramiprosate in rat plasma. Pre-column derivatization of
M Foster Olive et al.
European journal of pharmacology, 437(1-2), 55-61 (2002-02-28)
The purpose of the present study was to determine the acute effects of the anticraving compound acamprosate (calcium acetylhomotaurinate) and the closely related compound homotaurine on ethanol intake and ethanol-stimulated dopamine release in the nucleus accumbens. Male rats were treated

Questions

1–2 of 2 Questions  
  1. What other solvent can dissolve this compound besides water?

    1 answer
    1. This compound can also be dissolved in DMSO. However, the concentration at which it can be dissolved in DMSO has not been determined.

      Helpful?

  2. In which solvent,this compound dissolved except water?

    1 answer
    1. This chemical can also be solubilized in DMSO. The concentration at which it can be solubilized in DMSO is not determined.

      Helpful?

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