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Key Documents

210358

Sigma-Aldrich

4-Chloro-N-methylaniline

97%

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About This Item

Linear Formula:
ClC6H4NHCH3
CAS Number:
Molecular Weight:
141.60
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:

assay

97%

form

liquid

refractive index

n20/D 1.584 (lit.)

bp

239 °C (lit.)

density

1.169 g/mL at 25 °C (lit.)

SMILES string

CNc1ccc(Cl)cc1

InChI

1S/C7H8ClN/c1-9-7-4-2-6(8)3-5-7/h2-5,9H,1H3

InChI key

XCEYKKJMLOFDSS-UHFFFAOYSA-N

signalword

Danger

Hazard Classifications

Aquatic Chronic 3 - Eye Dam. 1 - Flam. Liq. 3 - STOT SE 3

target_organs

Respiratory system

Storage Class

3 - Flammable liquids

wgk_germany

WGK 3

flash_point_f

125.6 °F - closed cup

flash_point_c

52 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter


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C Varshneya et al.
Toxicology letters, 31(2), 107-111 (1986-05-01)
White leghorn cockerels were fed a diet containing 0, 400, 800 and 1600 ppm of malathion for 90 days. Malathion O,O-dimethyl S-(1,2-dicarbethoxy) ethyl phosphorodithioate) at 800 and 1600 ppm caused a significant decrease in body weights. There was a significant
M Weiner et al.
Drug metabolism and disposition: the biological fate of chemicals, 8(3), 139-142 (1980-05-01)
Hepatic metabolism of aniline, p-chloro-N-methylaniline, and aminopyrine was determined in control male, New Zealand White rabbits or those bearing VX2 carcinoma (a prostaglandin-secreting tumor). In addition, the levels of cyclic AMP and cyclic GMP in the liver and the concentration
Brian W Budzik et al.
Bioorganic & medicinal chemistry letters, 20(4), 1363-1367 (2010-01-26)
A series of 3-aryl-4-isoxazolecarboxamides identified from a high-throughput screening campaign as novel, potent agonists of the human TGR5 G-protein-coupled receptor is described. Many analogues were readily accessible via solution-phase synthesis which resulted in the rapid identification of key structure-activity relationships
One-pot synthesis of N-methylindoles from N-methylanilines and of benzofurans from phenols using transition-metal carbene X-H insertion reactions.
Honey MA, et al.
Tetrahedron, 65(44), 8995-9001 (2009)
C Jurincic et al.
Deutsche medizinische Wochenschrift (1946), 116(21), 816-818 (1991-05-24)
A 19-year-old and a 50-year-old man who together had cleaned a water-tank as part of their duties in a tank protection and cleaning firm developed that same evening lower abdominal pain, dysuria and haematuria. Cystoscopy revealed haemorrhagic cystitis in both

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