C22415

4-Chloroaniline

98%

• Synonym(s): 1-Amino-4-chlorobenzene, 4-Chlorophenylamine, p-Chloroaniline
• Linear Formula: ClC₆H₄NH₂
• CAS Number: 106-47-8
• Molecular Weight: 127.57
• Beilstein/REAXYS Number: 471359
• EC Number: 203-401-0
• MDL number: MFCD00007835
• UNSPSC Code: 12352100
• PubChem Substance ID: 24892480
• NACRES: NA.22

Properties

• vapor density: 4.4 (vs air)
• Quality Level: 200
• vapor pressure: 0.15 mmHg ( 25 °C)
• assay: 98%
• form: chips; crystals or chunks
• bp: 232 °C (lit.)
• mp: 67-70 °C (lit.)
• SMILES string: Nc1ccc(Cl)cc1
• InChI: 1S/C6H6ClN/c7-5-1-3-6(8)4-2-5/h1-4H,8H2
• InChI key: QSNSCYSYFYORTR-UHFFFAOYSA-N

Description

Application

4-Chloroaniline can undergo:

• Allylation in the presence of ultrasonication to form N-allyl-4-chloroaniline, a precursor for bioactive compounds containing indole and dihydroindole nucleus.
• Povarov reaction with cyclopentadiene to form C-2 aliphatic substituted tetrahydroquinolines.
• Mannich reaction with aldehydes and cyclic ketones to form β-amino carbonyl compounds.
• Nitration to form 4-chloro-3-nitroaniline in the presence of guanidinium nitrate.

Safety Information

• pictograms: GHS06,GHS08,GHS09
• signalword: Danger
• hcodes: H301 + H311 + H331,H317,H350,H410
• pcodes: P202 - P273 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B - Skin Sens. 1
• Storage Class: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk_germany: WGK 3
• flash_point_f: 248.0 °F - closed cup
• flash_point_c: 120.0 °C - closed cup
• ppe: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges