Key Documents

NBQX disodium salt hydrate

Name: NBQX disodium salt hydrate
Brand: SIGMA
Price: 370 USD
Availability: InStock

≥98% (HPLC), lyophilized powder, neuroprotective AMPA/kainate glutamate receptor antagonist

Synonym(s):

1,2,3,4-Tetrahydro-6-nitro-2,3-dioxo-benzo[f]quinoxaline-7-sulfonamide disodium salt hydrate, FG 9202 disodium salt hydrate

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Pack Size	SKU	Availability	Price
5 mg		Available to ship TODAYfromMILWAUKEE	$370.00
25 mg		Available to ship TODAYfromMILWAUKEE	$1,430.00

About This Item

Empirical Formula (Hill Notation):

C₁₂H₆N₄Na₂O₆S · xH₂O

CAS Number:

118876-58-7

Molecular Weight:

380.24 (anhydrous basis)

UNSPSC Code:

12352200

PubChem Substance ID:

24277996

NACRES:

NA.77

MDL number:

MFCD12910445

Assay:

≥98% (HPLC)

Form:

lyophilized powder

Storage condition:

desiccated

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Properties

Product Name

NBQX disodium salt hydrate, ≥98% (HPLC)

Quality Segment

100

assay

≥98% (HPLC)

form

lyophilized powder

storage condition

desiccated

color

, brown to dark red-brown

solubility

H₂O: >10 mg/mL

storage temp.

2-8°C

SMILES string

O.[Na+].[Na+].NS(=O)(=O)c1cccc2c1c(cc3nc([O-])c([O-])nc23)[N+]([O-])=O

InChI

1S/C12H8N4O6S.2Na.H2O/c13-23(21,22)8-3-1-2-5-9(8)7(16(19)20)4-6-10(5)15-12(18)11(17)14-6;;;/h1-4H,(H,14,17)(H,15,18)(H2,13,21,22);;;1H2/q;2*+1;/p-2

InChI key

LQSCHRKYVVVUFA-UHFFFAOYSA-L

Gene Information

human ... GRIA1(2890), GRIA2(2891), GRIA3(2892), GRIA4(2893), GRIK1(2897), GRIK2(2898), GRIK3(2899), GRIK4(2900), GRIK5(2901)

Description

Application

NBQX disodium salt hydrate has been used:

in N-methyl-D-aspartate receptor (NMDAR) kinetic studies
as an α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist for the electrophysiological studies cultured neurons
in the extracellular solution for current/voltage (I/V) relationship and rectification index experiments in excitatory postsynaptic currents (EPSCs) mediated by NMDA receptors (EPSC_NMDAR)

Biochem/physiol Actions

NBQX disodium salt hydrate is a neuroprotective AMPA/kainate glutamate receptor antagonist.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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This Item	C239	N171	P1999
Sigma-Aldrich N183 NBQX disodium salt hydrate	Sigma-Aldrich C239 CNQX disodium salt hydrate	Sigma-Aldrich N171 NBQX hydrate	Sigma-Aldrich P1999 PEAQX tetrasodium hydrate
form lyophilized powder	form solid	form powder	form powder
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. -	storage temp. -	storage temp. −20°C
solubility H₂O: >10 mg/mL	solubility H₂O: >2 mg/mL (warmed)	solubility methanol: 0.25 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.5 mg/mL, DMSO: 4 mg/mL, H₂O: insoluble	solubility water: 10 mg/mL
storage condition desiccated	storage condition protect from light	storage condition -	storage condition desiccated