The product has a recommended retest date (similar to a shelf life date) of 2 years. The actual recommended retest date for each lot is on the Certificate of Analysis located at our website.
T8552
Trichostatin A
From Streptomyces sp., ≥98% (HPLC), Histone deacetylase (HDAC) inhibitor, powder
Synonym(s):
TSA, [R-(E,E)]-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide
Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 1 mg | Available to ship TODAYfromMILWAUKEE | $209.00 | |
| 5 mg | Available to ship TODAYfromMILWAUKEE | $678.00 |
About This Item
Empirical Formula (Hill Notation):
C17H22N2O3
CAS Number:
Molecular Weight:
302.37
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Product Name
Trichostatin A, ≥98% (HPLC), from Streptomyces sp.
biological source
Streptomyces sp.
Quality Level
assay
≥98% (HPLC)
form
powder
solubility
methanol: soluble 1.90-2.10 mg/mL, clear, colorless to faint yellow or tan, DMF: soluble, DMSO: soluble, H2O: insoluble, acetone: slightly soluble, acetonitrile: soluble, benzene: slightly soluble, chloroform: slightly soluble, ethanol: soluble, ethyl acetate: slightly soluble, lower alcohols: soluble
storage temp.
−20°C
SMILES string
C[C@H](\C=C(C)\C=C\C(=O)NO)C(=O)c1ccc(cc1)N(C)C
InChI
1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-11,13,22H,1-4H3,(H,18,20)/b10-5+,12-11+/t13-/m1/s1
InChI key
RTKIYFITIVXBLE-QEQCGCAPSA-N
Gene Information
human ... HDAC1(3065), HDAC4(9759), HDAC6(10013), HDAC8(55869)
mouse ... ENSMUSG00000061062(15181)
rat ... Hdac7a(84582)
General description
Trichostatin A (TSA) is a potent and specific inhibitor of histone deacetylase (HDAC) activity. It is an antifungal antibiotic with cytostatic and differentiating properties in mammalian cell culture.[1]
Application
Biochem/physiol Actions
Trichostatin A (TSA) inhibits histone deacetylase at nanomolar concentrations; resultant histone hyperacetylation leads to chromatin relaxation and modulation of gene expression. May be involved in cell cycle progression of several cell types, inducing cell growth arrest at both G and G/M phases; may induce apoptosis. Enhances the efficacy of anticancer agents that target DNA. Trichostatin A serves as an epigenetic modifier.
Trichostatin A inhibits histone deacetylase at nanomolar concentrations; resultant histone hyperacetylation leads to chromatin relaxation and modulation of gene expression.
Features and Benefits
This compound is a featured product for Apoptosis and Gene Regulation research. Discover more featured Apoptosis and Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
Preparation Note
Trichostatin A is soluble in methanol at 1.90 - 2.10 mg/ml and yields a clear, colorless to faint yellow/tan solution. It is also soluble in DMSO, DMF, acetonitrile, ethanol and lower alcohols. Trichostatin A is sparingly soluble in chloroform, ethyl acetate, acetone, and benzene. However, it is insoluble in water.
1 of 1
This Item | |||
|---|---|---|---|
| form powder | form lyophilized solid | form solid | form powder |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| Quality Level 300 | Quality Level 100 | Quality Level 200 | Quality Level 200 |
| storage temp. −20°C | storage temp. −20°C | storage temp. 2-8°C | storage temp. −20°C |
| solubility methanol: soluble 1.90-2.10 mg/mL, clear, colorless to faint yellow or tan, DMSO: soluble, acetone: slightly soluble, benzene: slightly soluble, lower alcohols: soluble, DMF: soluble, acetonitrile: soluble, ethyl acetate: slightly soluble, H2O: insoluble, chloroform: slightly soluble | solubility ethanol: 1 mg/mL, DMSO: 20 mg/mL, methanol: soluble | solubility DMSO: soluble 0.90-1.10 mg/mL, clear, colorless, H2O: moderately soluble, aqueous acid: moderately soluble, ethanol: moderately soluble, methanol: moderately soluble | solubility DMSO: soluble, H2O: insoluble, acetone: soluble, chloroform: soluble, ethyl acetate: soluble |
| Gene Information human ... HDAC1(3065), HDAC4(9759), HDAC6(10013), HDAC8(55869) | Gene Information - | Gene Information - | Gene Information - |
Still not finding the right product?
Explore all of our products under Trichostatin A
Storage Class
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Articles
Cell cycle phases (G1, S, G2, M) regulate cell growth, DNA replication, and division in proliferating cells.
Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete.
Apoptosis regulation involves multiple pathways and molecules for cellular homeostasis.
Related Content
D M Vigushin et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 7(4), 971-976 (2001-04-20)
Trichostatin A (TSA), an antifungal antibiotic with cytostatic and differentiating properties in mammalian cell culture, is a potent and specific inhibitor of histone deacetylase (HDAC) activity. The purpose of this study was to evaluate the antiproliferative and HDAC inhibitory activity
Teena Haritwal et al.
International journal of radiation biology, 95(4), 443-451 (2018-10-12)
Ionizing radiation is known to damage male reproductive system. Current study aims to study the mitigative effects of trichostatin A on male reproductive system and accompanying metabolite changes in testicular tissue of mice. Eight-week-old male C57 Bl/6J mice were exposed
Cheng Liu et al.
Cancer research, 67(6), 2626-2631 (2007-03-17)
Recent evidence has accumulated that the dynamic histone methylation mediated by histone methyltransferases and demethylases plays key roles in regulation of chromatin structure and transcription. In the present study, we show that SET and MYND domain-containing protein 3 (SMYD3), a
Global Trade Item Number
| SKU | GTIN |
|---|---|
| T8552-1MG | 04061837379338 |
| T8552-5MG | 04061838446640 |
-
What is the shelf life of Product No. T8552, Trichostatin A?
1 answer-
Helpful?
-
-
How can I solubilize Product T8552, Trichostatin A?
1 answer-
Trichostatin A is soluble in dimethyl sulfoxide (DMSO) and in ethanol, each at 1 mg/mL. It is also soluble in methanol at 2 mg/mL. It is insoluble in water. Additional solubility information can be found on the data sheet on our website.
Helpful?
-
-
What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
Helpful?
-
-
At what concentration can Product T8552, Trichostatin A, be used as an inhibitor of histone deacetylase?
1 answer-
Trichostatin A inhibits histone deacetylase at nanomolar concentrations. Additional information may be found in the literature references cited on the product detail page for T8552.
Helpful?
-
-
Has Product T8552, Trichostatin A been endotoxin tested?
1 answer-
Product T8552 has not been tested for any endotoxin levels, nor has it been cell culture tested.
Helpful?
-
-
How should solutions of Trichostatin A, Product T8552, be stored?
1 answer-
Solutions at a concentration of 2 mg/mL in DMSO can be divided into aliquots and stored frozen at -20°C.
Helpful?
-