T0909

Tenoxicam

NSAID

• Synonym(s): 4-Hydroxy-2-methyl-N-2-pyridinyl-2H-thieno(2,3-e)-1,2-thiazine-3-carboxamide 1,1-dioxide
• Empirical Formula (Hill Notation): C₁₃H₁₁N₃O₄S₂
• CAS Number: 59804-37-4
• Molecular Weight: 337.37
• NACRES: NA.77
• PubChem Substance ID: 24899922
• UNSPSC Code: 12352202
• MDL number: MFCD00083502

Properties

• Quality Level: 100
• assay: ≥98% (perchloric acid titration)
• form: powder
• solubility: DMF: 25 mg/mL, clear, yellow-green
• SMILES string: O=C(NC1=NC=CC=C1)C2=C(O)C(SC=C3)=C3S(N2C)(=O)=O
• InChI: 1S/C13H11N3O4S2/c1-16-10(13(18)15-9-4-2-3-6-14-9)11(17)12-8(5-7-21-12)22(16,19)20/h2-7,17H,1H3,(H,14,15,18)
• InChI key: LZNWYQJJBLGYLT-UHFFFAOYSA-N

Description

Application

Tenoxicam has been used:

• as a non-steroidal anti-inflammatory agent (NSAID) to study its effects on root gravitropism in Arabidopsis thaliana[1]
• as a standard in microanalysis of NSAIDs by spectrophotometry
• to test its effect on surface potential andmembrane fluidity modification in phosphoglyceride monolayers[2]

Biochem/physiol Actions

Non-steroidal antiinflammatory drug (NSAID) with comparatively low risk of renal or hepatic toxicity.

Tenoxicam (TX) possesses antipyretic and analgesic effects. It elicits radical scavenging activity and has the potential to treat enkylosing spondylitis, extra-articular diseases, acute gout, and rheumatic diseases. It is also effective in treating primary dysmenorrhea, postpartum uterine contraction pain, and post-operation backaches.[3] TX is capable of inhibiting prostaglandin synthesis.[4]

Safety Information

• pictograms: GHS06
• signalword: Danger
• hcodes: H301 + H311 + H331
• pcodes: P261 - P264 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 2
• ppe: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges