SML0229

CIQ

≥98% (HPLC)

• Synonym(s): (3-Chlorophenyl)[3,4-dihydro-6,7-dimethoxy-1-[(4-methoxyphenoxy)methyl]-2(1H)-isoquinolinyl]-methanone
• Empirical Formula (Hill Notation): C₂₆H₂₆ClNO₅
• CAS Number: 486427-17-2
• Molecular Weight: 467.94
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: ≥10 mg/mL at warmed to 60 °C
• storage temp.: 2-8°C
• SMILES string: Clc1cc(ccc1)C(=O)N2CCc3c(cc(c(c3)OC)OC)C2COc4ccc(cc4)OC
• InChI: 1S/C26H26ClNO5/c1-30-20-7-9-21(10-8-20)33-16-23-22-15-25(32-3)24(31-2)14-17(22)11-12-28(23)26(29)18-5-4-6-19(27)13-18/h4-10,13-15,23H,11-12,16H2,1-3H3
• InChI key: VYMILMYEENZHAR-UHFFFAOYSA-N

Description

Biochem/physiol Actions

CIQ is a selective NR2C/NR2D-containing NMDA potentiator

CIQ is positive allosteric modulator of NR2C/NR2D subunit containing NMDA receptors. CIQ increases channel opening frequency of recombinant NR2Cor NR2D containing receptors by two-fold (EC₅₀ = 2.7 and 2.8 μM, respectively), with no effect on NR2A or NR2B subtypes. The compound does not alter the EC₅₀ values for glutamate or glycine on channel opening.

Features and Benefits

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This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable