P51559

Propionyl chloride

98%

• Synonym(s): Chloro ethyl ketone, Ethyl chloroform, Propionic acid chloride, Prorionyl chloride
• Linear Formula: CH₃CH₂COCl
• CAS Number: 79-03-8
• Molecular Weight: 92.52
• Beilstein/REAXYS Number: 385632
• EC Number: 201-170-0
• MDL number: MFCD00000745
• UNSPSC Code: 12352100
• PubChem Substance ID: 24898602
• NACRES: NA.22

Properties

• vapor density: 3.2 (vs air)
• Quality Level: 200
• assay: 98%
• refractive index: n20/D 1.404 (lit.)
• bp: 77-79 °C (lit.)
• mp: −94 °C
• density: 1.059 g/mL at 25 °C (lit.)
• SMILES string: CCC(Cl)=O
• InChI: 1S/C3H5ClO/c1-2-3(4)5/h2H2,1H3
• InChI key: RZWZRACFZGVKFM-UHFFFAOYSA-N

Description

General description

Propionyl chloride is an important chemical intermediate used to synthesize various propionic acid derivatives.

Application

Propionyl chloride can be used as an acylating agent:

• To convert anisole to 4-methoxypropiophenone and 2-methoxynaphthalene to 1-propio-2-methoxynaphthalene in the presence of Indium(III) chloride (InCl₃) impregnated mesoporous Si-MCM-41 catalyst.

It can also be used:

• For chlorination in the presence of sulfuryl chloride and peroxides to form α-chloropropionyl chloride and β-chloropropionyl chloride.
• In reaction with (hydroxypropyl)cellulose to form the propanoate ester, [(propionyloxy)propyl]cellulose.

Safety Information

• pictograms: GHS02,GHS06,GHS05
• signalword: Danger
• hcodes: H225,H302,H314,H331
• pcodes: P210 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B
• supp_hazards: EUH014
• Storage Class: 3 - Flammable liquids
• wgk_germany: WGK 1
• flash_point_f: 42.8 °F - closed cup
• flash_point_c: 6 °C - closed cup
• ppe: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter