The acceptable temperature range for products stored at -20°C is -10°C to -25°C. The stability of this product in solution has not been investigated. However, external sources indicate that stock solutions prepared in DMSO are stable for 6 months when stored at -20°C. The same acceptable range would apply.
S4317
SB 431542 hydrate
≥98% (HPLC), powder, inhibits activation of SMAD proteins
Synonym(s):
4-(5-Benzol[1,3]dioxol-5-yl-4-pyrldin-2-yl-1H-imidazol-2-yl)-benzamide hydrate, 4-[4-(1,3-Benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]-benzamide hydrate, 4-[4-(3,4-Methylenedioxyphenyl)-5-(2-pyridyl)-1H-imidazol-2-yl]-benzamide hydrate
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 5 mg | Available to ship TODAYfromMILWAUKEE | $205.00 |
About This Item
Empirical Formula (Hill Notation):
C22H16N4O3 · xH2O
CAS Number:
Molecular Weight:
384.39 (anhydrous basis)
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Product Name
SB 431542 hydrate, ≥98% (HPLC), powder
Quality Segment
assay
≥98% (HPLC)
form
powder
solubility
DMSO: soluble 10 mg/mL, H2O: insoluble
originator
GlaxoSmithKline
storage temp.
−20°C
SMILES string
O.NC(=O)c1ccc(cc1)-c2nc(-c3ccc4OCOc4c3)c([nH]2)-c5ccccn5
InChI
1S/C22H16N4O3.H2O/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1-2-10-24-16)15-8-9-17-18(11-15)29-12-28-17;/h1-11H,12H2,(H2,23,27)(H,25,26);1H2
InChI key
WQUIJVKNPYBZOF-UHFFFAOYSA-N
Application
Biochem/physiol Actions
Potent and selective inhibitor of transforming growth factor-β superfamily type I activin receptor-like kinase (ALK) receptors.
Features and Benefits
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Legal Information
Sold for research purposes under agreement from GlaxoSmithKline
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This Item | |||
|---|---|---|---|
| form powder | form powder | form solid | form powder |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| Quality Level 300 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. −20°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility DMSO: soluble 10 mg/mL, H2O: insoluble | solubility DMSO: >10 mg/mL, H2O: insoluble | solubility DMSO: ≥12 mg/mL | solubility DMSO: ≥8 mg/mL |
| originator GlaxoSmithKline | originator GlaxoSmithKline | originator GlaxoSmithKline | originator GlaxoSmithKline |
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| S4317-5MG | 04061836925956 |
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Is it okay to store the original product and its aliquoted stock solutions not only at -20℃ specifically, but also in some temperature range around -20℃? Can I have certain temperature range for storage?
1 answer-
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If not reconstituted for how long can I store the vial?
1 answer-
This product is not assigned an expiration date or recommended retest date. Products with no expiration date or recommended retest date should be routinely inspected by customers to ensure they perform as expected. These products are also subject to a one-year warranty from the date of shipment. For more information, you may access the Product Dating Information document under ADDITIONAL USEFUL DOCUMENTS ABOUT OUR PRODUCTS at the bottom of the Quality Services page with this link: https://www.sigmaaldrich.com/life-science/quality-and-regulatory-management/quality-services.
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How long can I store the reconstituted compound in the freezer -20 degrees? i have one that was aliquoted 4 years ago. Is it still ok to use it ?
1 answer-
It is recommended, following reconstitution, to aliquot and freeze -20°C. The stock solutions are stable for up to 6 months at -20°C. The quality of solutions stored frozen for extended periods has not been evaluated. The end user would have to determine suitability. Any color change, cloudiness, or particulate matter present upon thawing would be a visual indicator of degradation.
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