Multiplbe genes encode different subtypes of serotonin (5HT) receptor and are species specific. HTR2B is expressed in mammalian brain and is localized to GABA (γ-aminobutyric acid) producing neurons of dorsal hypothalamic nucleus. The HTR2B gene is mapped to human chromosome 2q37.1.
Immunogen
synthetic peptide corresponding to the second extracellular loop of human serotonin 5-HT2B receptor, conjugated KLH. The immunizing peptide has 80% homology with the rat gene and 93% homology with the mouse gene.
Biochem/physiol Actions
The functions of serotonin (5HT) receptors are associated with sleep disorders, anxiety, depression and schizophrenia.
Target description
The Serotonin 5-HT2B Receptor regulates cardiomyocyte development and growth. Activation of 5-HT2B receptors may also contribute to initiation of sleep and to theta generation during W and PS under physiological conditions.
Physical form
solution in phosphate buffered saline containing ≤0.1% sodium azide
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Increased wakefulness, motor activity and decreased theta activity after blockade of the 5-HT2B receptor by the subtype-selective antagonist SB-215505.
Kantor S, et al.
British Journal of Pharmacology, 142(8), 1332-1342 (2004)
Prenatal diagnosis of microdeletion 16p13.11 combination with partial monosomy of 2q37.1-qter and partial trisomy of 7p15.3-pter in a fetus with bilateral ventriculomegaly, agenesis of corpus callosum, and polydactyly.
Sung P L, et al.
Taiwanese Journal of Obstetrics & Gynecology, 51(2), 260-265 (2012)
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