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14927

Supelco

Serotonin

analytical standard

Synonym(s):

3-(2-Aminoethyl)-5-hydroxyindole, 5-HT, 5-Hydroxytryptamine

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25 MG
$125.00

$125.00

Estimated to ship onMarch 28, 2025

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25 MG
$125.00

About This Item

Empirical Formula (Hill Notation):
C10H12N2O
CAS Number:
50-67-9
Molecular Weight:
176.22
Beilstein/REAXYS Number:
143524
EC Number:
200-058-9
MDL number:
MFCD00055054
UNSPSC Code:
85151701
PubChem Substance ID:
329750658
NACRES:
NA.24

$125.00

Estimated to ship onMarch 28, 2025

Request a Bulk Order

grade

analytical standard

Quality Level

100

assay

≥95.0% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

impurities

≤1.0% water (calc. from elemental analysis)

format

neat

storage temp.

2-8°C

SMILES string

OC1=CC=C(NC=C2CCN)C2=C1

InChI

1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2

InChI key

QZAYGJVTTNCVMB-UHFFFAOYSA-N

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General description

Serotonin, also known as 5-hydroxytryptamine, is an important biogenic monoamine neurotransmitter and a neuromodulator, found in the central nervous system. It is involved in regulating various physiological processes such as appetite, anxiety, sleep, mood, and blood pressure. A decrease in serotonin levels might result in disorders such as obesity, schizophrenia, and depression.

Application

This analytical standard can also be used as follows:
  • Electrochemical detection of serotonin in urine samples using a glassy carbon electrode (GCE) coated with multiwalled-carbon-nanotubes (MWCNT) doped with nickel, zinc, and iron oxide nanoparticles by a cyclic voltammetry procedure
  • Development and validation of an ultra high-performance liquid chromatography-tandem mass spectrometry method to determine serotonin in raw and roasted samples of a variety of nuts, along with commercial nut products
  • Designing of RuO2 nanowires/CeO2-AuNFs nanofibers/graphene oxide/functionalized multiwalled carbon nanotubes modified screen-printed carbon electrode for the multi-residue analysis of serotonin, dopamine, and ascorbic acid in cerebrospinal fluid and vitamin C tablet samples
  • Construction of a low-cost glassy carbon electrode (GCE) modified with a nanoparticulate film of nanodiamonds and gold nanoparticles anchored to GCE using casein for the quantification of serotonin in urine samples
  • Determination of serotonin in urine samples using a two-dimensional capillary isotachophoresis-capillary zone electrophoresis procedure coupled with tandem mass spectrometry (MS/MS)

Other Notes

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

hcodes

H301,H361

Hazard Classifications

Acute Tox. 3 Oral - Repr. 2

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
BCCL7170
BCCL5779
BCCJ2894
BCCG9008
BCCF8292

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Ekaterina Savchenko et al.
Disease models & mechanisms, 10(9), 1089-1100 (2017-07-25)
Neural stem/progenitor cells (NPCs) generate new neurons in the brain throughout an individual's lifetime in an intricate process called neurogenesis. Neurogenic alterations are a common feature of several adult-onset neurodegenerative diseases. The neuronal ceroid lipofuscinoses (NCLs) are the most common
Dolors Llobet et al.
Thrombosis research, 181, 99-105 (2019-08-06)
Platelet hyper-reactivity has been associated with thrombosis and high levels of human vesicle-associated membrane protein 8 (VAMP8) and serotonin transporter (SERT). Two polymorphisms (rs1010 of VAMP8 gene and in SERT gene (SLC6A4)) are associated with arterial thrombosis. To determine if
Dwight F Newton et al.
Psychopharmacology, 234(4), 647-656 (2016-12-14)
Executive dysfunction is common and impairing in youth bipolar disorder (BD), and oxidative stress (OS) and brain-derived neurotrophic factor (BDNF) have been implicated in executive deficits of adult BD. This study aimed to determine the association between OS and executive
Eric D Melonakos et al.
Hippocampus, 29(9), 773-786 (2018-11-13)
Sharp wave-ripples (140-220 Hz) are patterns of brain activity observed in the local field potential of the hippocampus which are present during memory consolidation. As rodents switch from memory consolidation to memory encoding behaviors, cholinergic inputs to the hippocampus from neurons
Yongtao Bai et al.
Biomedical chromatography : BMC, 33(9), e4542-e4542 (2019-04-05)
A highly selective and efficient LC-MS/MS method was developed to determine the plasma concentration of magnolol, hesperidin, neohesperidin and geniposide following oral administration of Zhi-Zi-Hou-Po decoction in normal and depressed rats. Plasma samples were pretreated by protein precipitation with methanol.
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Questions

1–3 of 3 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. Dear Sirs: What is the solubility of standard serotonin? Greetings

    1 answer

    1. This product is not tested for solubility. However, various sources state that Serotonin is generally soluble in methanol, slightly soluble in water, DMSO, and chloroform. The exact concentrations at which it can be solubilized is not determined.

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