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S0445

Sigma-Aldrich

Anti-Serotonin 5-HT2B Receptor antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-5-HT(2B), Anti-5-HT-2B, Anti-5-HT2B

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About This Item

MDL number:
MFCD01865274
UNSPSC Code:
12352203

biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

availability

not available in Japan

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 4-6 μg/mL using human brain, neurons and glia

UniProt accession no.

P41595

shipped in

wet ice

storage temp.

−70°C

target post-translational modification

unmodified

Gene Information

human ... HTR2B(3357)
mouse ... Htr2b(15559)
rat ... Htr2b(29581)

General description

Multiplbe genes encode different subtypes of serotonin (5HT) receptor and are species specific. HTR2B is expressed in mammalian brain and is localized to GABA (γ-aminobutyric acid) producing neurons of dorsal hypothalamic nucleus. The HTR2B gene is mapped to human chromosome 2q37.1.

Immunogen

synthetic peptide corresponding to the second extracellular loop of human serotonin 5-HT2B receptor, conjugated KLH. The immunizing peptide has 80% homology with the rat gene and 93% homology with the mouse gene.

Biochem/physiol Actions

The functions of serotonin (5HT) receptors are associated with sleep disorders, anxiety, depression and schizophrenia.

Target description

The Serotonin 5-HT2B Receptor regulates cardiomyocyte development and growth. Activation of 5-HT2B receptors may also contribute to initiation of sleep and to theta generation during W and PS under physiological conditions.

Physical form

solution in phosphate buffered saline containing ≤0.1% sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Multiple serotonin receptor subtypes: molecular cloning and functional expression.
Teitler M and Herrick-Davis K
Critical Reviews in Neurobiology, 8(3), 175-188 (1994)
Serotonin receptors and their function in sleep, anxiety disorders and depression.
Leonard B E, et al.
Psychotherapy and Psychosomatics, 65(2), 66-75 (1996)
Increased wakefulness, motor activity and decreased theta activity after blockade of the 5-HT2B receptor by the subtype-selective antagonist SB-215505.
Kantor S, et al.
British Journal of Pharmacology, 142(8), 1332-1342 (2004)
Prenatal diagnosis of microdeletion 16p13.11 combination with partial monosomy of 2q37.1-qter and partial trisomy of 7p15.3-pter in a fetus with bilateral ventriculomegaly, agenesis of corpus callosum, and polydactyly.
Sung P L, et al.
Taiwanese Journal of Obstetrics & Gynecology, 51(2), 260-265 (2012)

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