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R116

Riluzole

≥98% (HPLC), solid, glutamate release inhibitor

Synonym(s):

2-Amino-6-(trifluoromethoxy)benzothiazole

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25 mg

Available to ship TODAYfromMILWAUKEE

$105.00
250 mg

Available to ship TODAYfromMILWAUKEE

$779.00
500 mg

Available to ship TODAYfromMILWAUKEE

$915.00

About This Item

Empirical Formula (Hill Notation):
C8H5F3N2OS
CAS Number:
1744-22-5
Molecular Weight:
234.20
UNSPSC Code:
12352200
PubChem Substance ID:
24278006
NACRES:
NA.77
MDL number:
MFCD00210213
Form:
solid
Quality level:
100

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Product Name

Riluzole, solid

form

solid

Quality Level

100

originator

Sanofi Aventis

SMILES string

Nc1nc2ccc(OC(F)(F)F)cc2s1

InChI

1S/C8H5F3N2OS/c9-8(10,11)14-4-1-2-5-6(3-4)15-7(12)13-5/h1-3H,(H2,12,13)

InChI key

FTALBRSUTCGOEG-UHFFFAOYSA-N

Gene Information

human ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)
rat ... Scnn1g(24768)

Biochem/physiol Actions

Glutamate release inhibitor; anticonvulsant

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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This Item
557324PHR24991604337
Riluzole solid

Sigma-Aldrich

R116

Riluzole

Riluzole A cell-permeable benzothiazole compound that potently inhibits glutamate release and blocks Na+ channels.

Sigma-Aldrich

557324

Riluzole

Riluzole Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR2499

Riluzole

Riluzole United States Pharmacopeia (USP) Reference Standard

USP

1604337

Riluzole

form

solid

form

solid

form

solid

form

-

Quality Level

100

Quality Level

100

Quality Level

300

Quality Level

-

originator

Sanofi Aventis

originator

-

originator

-

originator

-

Gene Information

human ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)
rat ... Scnn1g(24768)

Gene Information

-

Gene Information

-

Gene Information

human ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)

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pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H300

Hazard Classifications

Acute Tox. 2 Oral

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
0000542308
0000542303
0000542306
0000542308
0000542303

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Ryan S Phillips et al.
eLife, 11 (2022-07-08)
Previously our computational modeling studies (Phillips et al., 2019) proposed that neuronal persistent sodium current (INaP) and calcium-activated non-selective cation current (ICAN) are key biophysical factors that, respectively, generate inspiratory rhythm and burst pattern in the mammalian preBötzinger complex (preBötC)
B C Cheah et al.
Current medicinal chemistry, 17(18), 1942-1199 (2010-04-10)
Amyotrophic lateral sclerosis (ALS) is a universally fatal neurodegenerative disease of the human motor system. Aetiological mechanisms implicated in the development of ALS have been linked to the glutamatergic neurotransmitter system, with destruction of motor neurons triggered through excessive activation
Arun Pal et al.
Life science alliance, 7(8) (2024-05-18)
Amyotrophic lateral sclerosis (ALS) leads to death within 2-5 yr. Currently, available drugs only slightly prolong survival. We present novel insights into the pathophysiology of Superoxide Dismutase 1 (SOD1)- and in particular Fused In Sarcoma (FUS)-ALS by revealing a supposedly
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Global Trade Item Number

SKUGTIN
R116-250MG04061832093116
R116-500MG04061836694241
R116-25MG04061836694227
R1030-200UL04061836265588

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