Pentylenetetrazole induced convulsions have been reported by De Sarro G. et al., in Eur. J. Pharmacol., 368(2-3),149-159 (1999).
P6500
Pentylenetetrazole
≥99% (GC), powder, CNS stimulant
Synonym(s):
α,β-Cyclopentamethylenetetrazole, 1,5-Pentamethylenetetrazole, 6,7,8,9-Tetrahydro-5H-tetrazolo[1,5-a]azepine, Metrazole
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 25 g | Available to ship TODAYfromMILWAUKEE | $108.00 | |
| 50 g | Available to ship TODAYfromMILWAUKEE | $218.00 | |
| 100 g | Available to ship TODAYfromMILWAUKEE | $403.00 $342.55 |
About This Item
Empirical Formula (Hill Notation):
C6H10N4
CAS Number:
Molecular Weight:
138.17
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
200-219-3
MDL number:
Form:
powder
Product Name
Pentylenetetrazole,
form
powder
Quality Segment
bp
194 °C/12 mmHg (lit.)
mp
59-61 °C (lit.)
storage temp.
−20°C
SMILES string
C1CCc2nnnn2CC1
InChI
1S/C6H10N4/c1-2-4-6-7-8-9-10(6)5-3-1/h1-5H2
InChI key
CWRVKFFCRWGWCS-UHFFFAOYSA-N
General description
Pentylenetetrazole (PTZ) is a tetrazole derivative and inhibitor of the γ aminobutyric acid (GABAA) and its receptor complex. PTZ is a convulsing agent used for inducing seizures.[1] It can traverse the blood-brain barrier.
Application
Pentylenetetrazole has been used to induce seizures in zebra fish larvae, mice, and male wistar rats.
Biochem/physiol Actions
Pentylenetetrazole is a non-specific central nervous system (CNS) stimulant and convulsant. PTZ induces oxidative stress and increases cortical malondialdehyde content and affects hippocampus, resulting in seizures.
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This Item | |||
|---|---|---|---|
| form powder | form solid | form powder | form liquid |
| Quality Level 100 | Quality Level 100 | Quality Level 200 | Quality Level 100 |
| storage temp. −20°C | storage temp. 2-8°C | storage temp. - | storage temp. −20°C |
| bp 194 °C/12 mmHg (lit.) | bp - | bp - | bp - |
| mp 59-61 °C (lit.) | mp - | mp - | mp - |
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| P6500-100G | 04061834393481 |
| P6500-25G | 04061834393498 |
| P6500-50G | 04061834393504 |
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Can Product P6500, Pentylenetetrazole, be used to induce convulsions?
1 answer-
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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How do I solubilize Product P6500, Pentylenetetrazole?
1 answer-
We test the solubility of this compound at a concentration of 50 mg/mL in water.
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What is the solution stability for Product P6500, Pentylenetetrazole?
1 answer-
We do not have any solution stability information for this product. It is always best to make a fresh solution. If this is not possible, you can try storing solution in single use aliquots at -20°C.
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