This product is not tested for potency on a lot-to-lot basis. However, historical information reports potencies ranging from 710-740 mcg/mg.
P5396
Phosphomycin disodium salt
antibacterial MurA inhibitor
Synonym(s):
(−)-(1R,2S)-(1,2-Epoxypropyl)phosphonic acid, Fosfomycin, Phosphonomycin
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About This Item
Empirical Formula (Hill Notation):
C3H5Na2O4P
Molecular Weight:
182.02
UNSPSC Code:
51102829
NACRES:
NA.85
PubChem Substance ID:
EC Number:
247-409-2
Beilstein/REAXYS Number:
4604425
MDL number:
Pricing and availability is not currently available.
Quality Level
form
powder
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria
mode of action
cell wall synthesis | interferes
storage temp.
2-8°C
SMILES string
[Na+].[Na+].C[C@@H]1O[C@@H]1P([O-])([O-])=O
InChI
1S/C3H7O4P.2Na/c1-2-3(7-2)8(4,5)6;;/h2-3H,1H3,(H2,4,5,6);;/q;2*+1/p-2/t2-,3+;;/m0../s1
InChI key
QZIQJIKUVJMTDG-JSTPYPERSA-L
Application
Phosphomycin, also known as Fosfomycin, is an antibiotic produced by Streptomyces fradiae. It is used to treat uncomplicated urinary tract infections. It is used for susceptibility studies of Klebsiella pneumoniae[1] and to study in vitro susceptibility testing procedures for fosfomycin tromethamine[2].
Biochem/physiol Actions
Antibiotic that concentrates in kidney and bladder; reduces nephrotoxicity and ototoxicity of platinum-containing anti-tumor agents. Fosfomycin is a phosphoenolpyruvate analog that irreversibly inhibits UDP-GlcNAc enolpyruvyl tranferase (MurA), an enzyme involved in bacterial cell wall biosynthesis. As a result, the production of N-acetylmuramic acid, an essential element of the peptidoglycan cell wall, is inhibited.
Other Notes
1g,5g,50g
Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.
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This Item | |||
|---|---|---|---|
| mode of action cell wall synthesis | interferes | mode of action - | mode of action - | mode of action - |
| antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria | antibiotic activity spectrum - | antibiotic activity spectrum - | antibiotic activity spectrum - |
| Quality Level 200 | Quality Level 100 | Quality Level - | Quality Level - |
| form powder | form - | form - | form - |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. - |
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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A L Barry et al.
Antimicrobial agents and chemotherapy, 35(6), 1235-1238 (1991-06-01)
Fosfomycin tromethamine (previously fosfomycin trometamol) is an orally administered fosfomycin which may be used for single-dose therapy of uncomplicated urinary tract infections. Fosfomycin tromethamine, norfloxacin, and trimethoprim-sulfamethoxazole inhibited greater than 90% of 352 bacterial isolates representing 25 different species; trimethoprim
Andrea Endimiani et al.
Antimicrobial agents and chemotherapy, 54(1), 526-529 (2009-11-11)
In vitro activity of fosfomycin was evaluated against 68 bla(KPC)-possessing Klebsiella pneumoniae (KpKPC) isolates, including 23 tigecycline- and/or colistin-nonsusceptible strains. By agar dilution, 93% of the overall KpKPC were susceptible (MIC(50/90) of 16/64 microg/ml, respectively). The subgroup of 23 tigecycline-
Nikos Fatsis-Kavalopoulos et al.
PLoS biology, 18(9), e3000856-e3000856 (2020-09-18)
Antibiotic combination therapies are important for the efficient treatment of many types of infections, including those caused by antibiotic-resistant pathogens. Combination treatment strategies are typically used under the assumption that synergies are conserved across species and strains, even though recent
Global Trade Item Number
| SKU | GTIN |
|---|---|
| P5396-50G | 04061832991924 |
| P5396-1G | 04061834379706 |
| P5396-5G | 04061834391630 |
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I want to know the potency of fosfomycin P5396-1G please tell the potency of this product
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