This compound is hydrophilic rather than lipophilic and demonstrates low cell permeability. Please see the link below to review a publication that may be of interest:
https://pubmed.ncbi.nlm.nih.gov/7955780/#:~:text=The%20hydrophilic%20nature%20of%20pravastatin,cross%20the%20blood%2Dbrain%20barrier.
P4498
Pravastatin sodium salt hydrate
synthetic (organic), ≥98% (HPLC), HMG-CoA reductase inhibitor, powder
Synonym(s):
(βR, δR,1S,2S,6S,8S,8aR)-1,2,6,7,8,8a-Hexahydro-β, δ,6-trihydroxy-2-methyl-8[(2S)-2-methyl-1-oxobutoxyl]-1-naphthaleneheptanoic acid sodium hydrate, Eptastatin sodium salt hydrate
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About This Item
Empirical Formula (Hill Notation):
C23H35O7Na · xH2O
CAS Number:
Molecular Weight:
446.51 (anhydrous basis)
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
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Product Name
Pravastatin sodium salt hydrate, ≥98% (HPLC), powder
biological source
synthetic (organic)
Quality Level
assay
≥98% (HPLC)
form
powder
color
white
mp
171.2-173 °C
solubility
H2O: >10 mg/mL
originator
Bristol-Myers Squibb
storage temp.
2-8°C
SMILES string
[Na+].[H][C@@](O)(CC[C@H]1[C@@H](C)C=CC2=C[C@@H](O)C[C@H](OC(=O)[C@@H](C)CC)[C@]12[H])C[C@@H](O)CC([O-])=O
InChI
1S/C23H36O7.Na/c1-4-13(2)23(29)30-20-11-17(25)9-15-6-5-14(3)19(22(15)20)8-7-16(24)10-18(26)12-21(27)28;/h5-6,9,13-14,16-20,22,24-26H,4,7-8,10-12H2,1-3H3,(H,27,28);/q;+1/p-1/t13-,14-,16+,17+,18+,19-,20-,22-;/m0./s1
InChI key
VWBQYTRBTXKKOG-IYNICTALSA-M
Gene Information
human ... HMGCR(3156)
Related Categories
1 of 4
This Item | |||
|---|---|---|---|
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay - |
| form powder | form crystalline solid | form powder | form - |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level - |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility H2O: >10 mg/mL | solubility water: 100 mg/mL | solubility H2O: ≥5 mg/mL | solubility - |
| originator Bristol-Myers Squibb | originator - | originator Bayer | originator - |
General description
Pravastatin sodium is an orally effective hypocholesterolaemic agent which is structurally similar to lovastatin and compactin.[1]
Application
Pravastatin sodium salt hydrate has been used in the enzymatic method to measure mevalonic acid in serum.[2]
Biochem/physiol Actions
Competitive, water-soluble 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor. Inhibits cholesterol synthesis in vivo (Ki ~1 nM).
Pravastatin sodium is a competitive, water-soluble 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor.[1]
Features and Benefits
This compound was developed by Bristol-Myers Squibb. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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[Dermatomyositis].
Sylvain Glitho et al.
La Revue du praticien, 63(5), 626-626 (2013-06-26)
Drug development for progeria yields insights into normal aging.
Kevin Jiang
Nature medicine, 19(5), 515-515 (2013-05-09)
Kevin F Erickson et al.
Journal of the American College of Cardiology, 61(12), 1250-1258 (2013-03-19)
The authors sought to evaluate the cost-effectiveness of statins for primary prevention of myocardial infarction (MI) and stroke in patients with chronic kidney disease (CKD). Patients with CKD have an elevated risk of MI and stroke. Although HMG Co-A reductase
S M Singhvi et al.
British journal of clinical pharmacology, 29(2), 239-243 (1990-02-01)
Pravastatin sodium, a competitive inhibitor of HMG-CoA reductase, is a new orally effective hypocholesterolaemic agent. In a two-way crossover study, eight healthy male subjects each received an intravenous and an oral dose of [14C]-pravastatin sodium. The oral absorption of [14C]
Statins for treating stable angina: can statins improve the plaque morphology and angina?
Cheol Whan Lee et al.
Future cardiology, 9(2), 155-158 (2013-03-08)
Articles
Discover Bioactive Small Molecules for Lipid Signaling Research
Cholesterol synthesis regulation by dietary levels, LDL receptors control lipid-rich LDL particle transport in cells.
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Is the Pravastatin sodium salt hydrate (Cat No.- P4498) cell permeable?
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