P0035

Penciclovir

• Synonym(s): 2-Amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)butyl]-6H-purin-6-one, BRL-39123
• Empirical Formula (Hill Notation): C₁₀H₁₅N₅O₃
• CAS Number: 39809-25-1
• Molecular Weight: 253.26
• NACRES: NA.76
• PubChem Substance ID: 329819986
• UNSPSC Code: 51102829
• MDL number: MFCD15142866

Properties

• form: powder
• Quality Segment: 100
• solubility: 0.02 M potassium phosphate: soluble 2 mg/mL
• antibiotic activity spectrum: viruses
• mode of action: DNA synthesis | interferes, enzyme | inhibits
• SMILES string: NC1=NC(=O)c2ncn(CCC(CO)CO)c2N1
• InChI: 1S/C10H15N5O3/c11-10-13-8-7(9(18)14-10)12-5-15(8)2-1-6(3-16)4-17/h5-6,16-17H,1-4H2,(H3,11,13,14,18)
• InChI key: JNTOCHDNEULJHD-UHFFFAOYSA-N

Description

Application

Penciclovir is a selective antiherpesvirus agent, particularly against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) and varicella-zoster virus (VZV)[1].

Biochem/physiol Actions

Penciclovir is converted to its active form, penciclovir triphosphate, by cellular kinases. It inhibits viral DNA polymerase by competing with deoxyguanosine triphosphate. It inhibits DNA synthesis of virus-infected cells. Penciclovir has in vitro activity against herpes simplex virus types 1 (HSV-1) and 2 (HSV-2). It does not inhibit DNA synthesis in non-infected cells. Mode of resistance is via qualitative changes in viral thymidine kinase or DNA polymerase[2].

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable