M9651

Maprotiline hydrochloride

>99% (HPLC), powder

• Synonym(s): 9-(γ-Methylaminopropyl)-9,10-dihydro-9,10-ethanoanthracene hydrochloride
• Empirical Formula (Hill Notation): C₂₀H₂₃N · HCl
• CAS Number: 10347-81-6
• Molecular Weight: 313.86
• NACRES: NA.77
• PubChem Substance ID: 24278576
• UNSPSC Code: 12352200
• EC Number: 233-758-8
• MDL number: MFCD00079464
• Assay: >99% (HPLC)
• Form: powder

Properties

• Quality Segment: 200
• assay: >99% (HPLC)
• form: powder
• color: white
• solubility: H₂O: 50 mg/mL
• originator: Novartis
• SMILES string: Cl.CNCCCC12CCC(c3ccccc13)c4ccccc24
• InChI: 1S/C20H23N.ClH/c1-21-14-6-12-20-13-11-15(16-7-2-4-9-18(16)20)17-8-3-5-10-19(17)20;/h2-5,7-10,15,21H,6,11-14H2,1H3;1H
• InChI key: NZDMFGKECODQRY-UHFFFAOYSA-N
• Gene Information: human ... SLC6A2(6530)

Description

Application

Maprotiline hydrochloride has been used as a inhibitor of norepinephrine uptake to study its effects on arresting L3055 cell proliferation.

Biochem/physiol Actions

Maprotiline is a tetracyclic agent. It possesses inhibitory effects against the uptake of norepinephrine by nerve cells. Maprotiline exhibits anti-depressant and sedative activity.

Features and Benefits

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves