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M3547

Mangiferin Mangifera indica

Synonym(s):

1,3,6,7-Tetrahydroxyxanthone C2-β-D-glucoside

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100 mg

Available to ship TODAYfromMILWAUKEE

$464.00
1 g

Available to ship TODAYfromMILWAUKEE

$464.00

About This Item

Empirical Formula (Hill Notation):
C19H18O11
CAS Number:
Molecular Weight:
422.34
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352205
MDL number:

$464.00


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assay

≥98% (TLC)

Quality Segment

form

powder

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

SMILES string

OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c2c(O)cc3Oc4cc(O)c(O)cc4C(=O)c3c2O

InChI

1S/C19H18O11/c20-4-11-15(25)17(27)18(28)19(30-11)12-8(23)3-10-13(16(12)26)14(24)5-1-6(21)7(22)2-9(5)29-10/h1-3,11,15,17-23,25-28H,4H2/t11-,15-,17+,18-,19+/m1/s1

InChI key

AEDDIBAIWPIIBD-ZJKJAXBQSA-N

General description

Mangiferin (MGF) is a natural bioactive polyphenol predominantly isolated from the Mangifera indica (Mango) tree.[1] It has a xanthone glucoside structure.[2] Mangiferin can also be found in other angiosperm plants and herbs.[3]

Application

Mangiferin has been used:
  • as a reference standard for the characterization of mangiferin from Mangifera indica using ultrasound with three-phase partitioning (UTPP)
  • to study its effects in promoting brown adipose phenotype murine C3H10T1/2 mesenchymal stem cells (MSCs) and its role in mitochondrial biogenesis and homeostasis[4]
  • as a reference standard for the quantitative determination of markers compounds in the culture Swertia paniculata shoot culture using high-performance thin-layer chromatography (HPTLC)[5]

Biochem/physiol Actions

Mangiferin has various pharmacological properties including antioxidant, anti-diabetic, anti-bacterial, cardioprotective, neuroprotective, and immunomodulatory activities.[1] It has also displayed antidiabetic, antihyperlipidemic, and antiatherogenic properties in streptozotocin-induced diabetic rats.[2] MGF exerts chemotherapeutic and chemo-preventative activities.[6] It displays antioxidant, analgesic, and hepatoprotective activity against carbon tetrachloride-induced liver injury.[7] MGF is a known accelerator of gastrointestinal transit (GIT).[8]

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06279PHL89729SMB00436
form

powder

form

-

form

solid

form

powder

assay

≥98% (TLC)

assay

≥98.0% (TLC)

assay

≥95.0% (HPLC)

assay

≥98% (HPLC)

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

application(s)

food and beverages

application(s)

-

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

Quality Level

200

Quality Level

100

Quality Level

-

Quality Level

200


pictograms

Skull and crossbones

signalword

Danger

hcodes

Hazard Classifications

Acute Tox. 1 Oral

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges



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Extraction of mangiferin from Mangifera indica leaves using three phase partitioning coupled with ultrasound
Kulkarni VM and Rathod VK
Industrial Crops and Products, 52, 292-297 (2014)
Ahsana Dar et al.
Biological & pharmaceutical bulletin, 28(4), 596-600 (2005-04-02)
Mangiferin, 2-beta-D-glucopyranosyl-1,3,6,7-tetrahydroxy-9H-xanthen-9-one, obtained directly from methanolic extracts of Bombax ceiba leaves in substantial amounts demonstrated strong antioxidant activity (EC(50) 5.8+/-0.96 mug/ml or 13.74 muM) using DPPH assay comparable to rutin, commonly used as antioxidant for medical purposes. The acetyl and
Md Shamim Rahman et al.
Metabolism: clinical and experimental, 107, 154228-154228 (2020-04-15)
Mangiferin (MF), a xanthonoid derived from Mangifera indica, has shown therapeutic effects on various human diseases including cancer, diabetes, and obesity. Nonetheless, the influence of MF on non-shivering thermogenesis and its underlying mechanism in browning remains unclear. Here, our aim



Global Trade Item Number

SKUGTIN
M3547-100MG04061838671561
M3547-1G04061834050407

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    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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