Key Documents

View All Documentation

Mefloquine hydrochloride

Name: Mefloquine hydrochloride
Brand: SIGMA
Price: 191 USD
Availability: InStock

≥98% (HPLC), Cx36 and Cx50 blocker, powder

Synonym(s):

(AS)-rel-a-(2R)-2-Piperidinyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol monohydrochloride

Select a Size

Change View

Pack Size	SKU	Availability	Price
100 mg		Available to ship TODAYfromMILWAUKEE	$191.00

About This Item

Empirical Formula (Hill Notation):

C₁₇H₁₇ClF₆N₂O

CAS Number:

51773-92-3

Molecular Weight:

414.77

NACRES:

NA.77

PubChem Substance ID:

24724536

UNSPSC Code:

12352202

EC Number:

257-412-0

MDL number:

MFCD00797519

Assay:

≥98% (HPLC)

Form:

powder

Storage condition:

desiccated

$191.00

Available to ship TODAYDetails

One Time Order

Request a Bulk Order

Subscriptions are currently unavailable.

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Properties

Product Name

Mefloquine hydrochloride, ≥98% (HPLC), powder

Quality Segment

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white

solubility

DMSO: soluble 38 mg/mL, H₂O: insoluble

SMILES string

Cl[H].[H][C@@]1(CCCCN1)[C@@H](O)c2cc(nc3c(cccc23)C(F)(F)F)C(F)(F)F

InChI

1S/C17H16F6N2O.ClH/c18-16(19,20)11-5-3-4-9-10(15(26)12-6-1-2-7-24-12)8-13(17(21,22)23)25-14(9)11;/h3-5,8,12,15,24,26H,1-2,6-7H2;1H/t12-,15+;/m1./s1

InChI key

WESWYMRNZNDGBX-YLCXCWDSSA-N

Description

Application

Mefloquine hydrochloride has been used:

to treat cochlear organotypic cultures with various doses to evaluate its role in cellular pathway involved in apoptosis
in screening for in vitro antischistosomal activity
in cytotoxicity assay of glioblastoma cells

Biochem/physiol Actions

Mefloquine is broadly used as an antimalarial drug. It inhibits 80S ribosomes of Plasmodium. It has numerous side effects like anxiety, dizziness, tremor, headache, and hearing loss. Mefloquine damages cochlear and vestibular hair cells through apoptosis. It also damages spiral ganglion neurons, degenerates cortical neuron and disrupts neuronal calcium homeostasis.

Blocker of gap junction channels Cx36 and Cx50.

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item	SML0283	SML1187	P3371
Sigma-Aldrich M2319 Mefloquine hydrochloride	Sigma-Aldrich SML0283 Amorolfine hydrochloride	Sigma-Aldrich SML1187 Vacquinol-1 dihydrochloride	Sigma-Aldrich P3371 Penfluridol
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥97% (HPLC)
form powder	form powder	form powder	form powder
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
solubility DMSO: soluble 38 mg/mL, H₂O: insoluble	solubility DMSO: ≥5 mg/mL (warmed)	solubility DMSO: 5 mg/mL, clear (warmed)	solubility DMSO: >20 mg/mL, H₂O: insoluble
storage condition desiccated	storage condition desiccated	storage condition -	storage condition -
color white	color white to beige	color white to beige	color white

Still not finding the right product?

Explore all of our products under Mefloquine hydrochloride

pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

0000294579

0000196117

0000134876

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Global Trade Item Number

SKU	GTIN
M2319-100MG	04061834041894

Questions

Reviews

No rating value