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K4013

Kasugamycin hydrochloride from Streptomyces kasugaensis

Synonym(s):

3-O-[2-Amino-4-[(carboxyiminomethyl)amino]-2,3,4,6-tetradeoxy-D-arabino-hexopyranosyl]-D-chiro-inositol

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Pack SizeSKUAvailabilityPrice
10 g

Available to ship TODAYfromMILWAUKEE

$449.00

About This Item

Empirical Formula (Hill Notation):
C14H25N3O9 · HCl
CAS Number:
19408-46-9
Molecular Weight:
415.82
NACRES:
NA.85
PubChem Substance ID:
24896238
UNSPSC Code:
51102829
MDL number:
MFCD00058459

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biological source

Streptomyces kasugaensis

Quality Level

200

form

powder

color

white to off-white

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

mode of action

protein synthesis | interferes

storage temp.

2-8°C

SMILES string

C[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)[C@@H]2O)[C@@H](N)C[C@@H]1NC(C(O)=O)=N.Cl

InChI

1S/C14H25N3O9.ClH/c1-3-5(17-12(16)13(23)24)2-4(15)14(25-3)26-11-9(21)7(19)6(18)8(20)10(11)22;/h3-11,14,18-22H,2,15H2,1H3,(H2,16,17)(H,23,24);1H/t3-,4+,5+,6-,7+,8+,9-,10+,11+,14-;/m1./s1

InChI key

ZDRBJJNXJOSCLR-NZXABURVSA-N

General description

Chemical structure: aminoglycoside

Application

Kasugamycin (Ksg) is an aminoglycoside antibiotic isolated from Streptomyces kasugaensis. It is used to study ribosome structure and interactions near the m26A m26A sequence[1]. It is used to study the mechanisms of kasugamycin resistance[2].

Biochem/physiol Actions

Kasugamycin binds within the mRNA channel of the 30S subunit between the universally conserved G926 and A794 nucleotides in 16S ribosomal RNA[2]. It inhibits protein synthesis and binding of aminoacyl-sRNA to the ribosomes in fungi and induces f-met-tRNA dissociation from the P-site of the 30S subunit.

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This Item
K1876K4000K1637
Kasugamycin hydrochloride from Streptomyces kasugaensis

Sigma-Aldrich

K4013

Kasugamycin hydrochloride from Streptomyces kasugaensis

Kanamycin disulfate salt from Streptomyces kanamyceticus aminoglycoside antibiotic

Sigma-Aldrich

K1876

Kanamycin disulfate salt from Streptomyces kanamyceticus

Kanamycin sulfate from Streptomyces kanamyceticus Animal Component-free

Sigma-Aldrich

K4000

Kanamycin sulfate from Streptomyces kanamyceticus

Kanamycin sulfate from Streptomyces kanamyceticus meets USP testing specifications, powder

Sigma-Aldrich

K1637

Kanamycin sulfate from Streptomyces kanamyceticus

mode of action

protein synthesis | interferes

mode of action

protein synthesis | interferes

mode of action

protein synthesis | interferes

mode of action

protein synthesis | interferes

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria, mycobacteria, mycoplasma

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria, mycobacteria, mycoplasma

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria, mycobacteria, mycoplasma

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

form

powder

form

powder

form

powder

form

powder

biological source

Streptomyces kasugaensis

biological source

Streptomyces kanamyceticus

biological source

Streptomyces kanamyceticus

biological source

Streptomyces kanamyceticus

storage temp.

2-8°C

storage temp.

-

storage temp.

-

storage temp.

-

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000488011
0000488011
0000430589
0000430589
0000367066

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Reiko Amikura et al.
Mechanisms of development, 122(10), 1087-1093 (2005-08-30)
In Drosophila, mitochondrially encoded ribosomal RNAs (mtrRNAs) form mitochondrial-type ribosomes on the polar granules, distinctive organelles of the germ plasm. Since a reduction in the amount of mtrRNA results in the failure of embryos to produce germline progenitors, or pole
Ceshing Sheu et al.
Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes, 45(5), 478-484 (2010-06-01)
A high performance liquid chromatographic (HPLC) analysis method with an ultraviolet (UV) detector and an Aqua C18 (250 x 4.6 mm, Phenomenex) column were applied to analyze the antibiotic fungicide kasugamycin in water. An aromatic sulfonic acid spe column (Backerbond
Atsushi Yoshii et al.
Applied and environmental microbiology, 78(16), 5555-5564 (2012-06-05)
Kasugamycin (KSM), a unique aminoglycoside antibiotic, has been used in agriculture for many years to control not only rice blast caused by the fungus Magnaporthe grisea but also rice bacterial grain and seedling rot or rice bacterial brown stripe caused
View All Related Papers

Global Trade Item Number

SKUGTIN
K4013-10G04061833944653

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