F0756

Fusidic acid

Antibiotic

• Synonym(s): Ramycin
• Empirical Formula (Hill Notation): C₃₁H₄₈O₆
• CAS Number: 6990-06-3
• Molecular Weight: 516.71
• NACRES: NA.77
• PubChem Substance ID: 57654174
• UNSPSC Code: 12352106
• EC Number: 230-256-0
• MDL number: MFCD00865135

Properties

• Product Name: Fusidic acid,
• Quality Segment: 200
• storage temp.: 2-8°C
• SMILES string: [H][C@@]12CC[C@@]3(C)[C@@]([H])([C@H](O)C[C@@]4([H])\C([C@H](C[C@]34C)OC(C)=O)=C(/CC\C=C(\C)C)C(O)=O)[C@@]1(C)CC[C@@H](O)[C@H]2C
• InChI: 1S/C31H48O6/c1-17(2)9-8-10-20(28(35)36)26-22-15-24(34)27-29(5)13-12-23(33)18(3)21(29)11-14-30(27,6)31(22,7)16-25(26)37-19(4)32/h9,18,21-25,27,33-34H,8,10-16H2,1-7H3,(H,35,36)/b26-20-/t18-,21-,22-,23+,24+,25-,27-,29-,30-,31-/m0/s1
• InChI key: IECPWNUMDGFDKC-MZJAQBGESA-N

Description

Application

Fusidic acid has been used:

• as a standard in thin-layer chromatography (TLC)-densitometric method
• to study its ability to bind to human serum albumin[1]
• as an antibiotic in combination with tannic acid to determine minimum inhibitory concentrations (MIC) in methicillin-resistant Staphylococcus aureus (MRSA)

Biochem/physiol Actions

Fusidic acid is a tetracyclic triterpenoid[2] with antibiotic activity against Gram-positive bacteria.[3] It is derived from Fusidium coccineum. It shows its activity against anaerobes, corynebacterial, Nocardia, and Neisseria species. Fusidic acid exhibits therapeutic effects against Staphylococcal infections, skin infections.[4]

Suppresses nitric oxide lysis of pancreatic islet cells. Inhibits protein synthesis in prokaryotes by inhibiting the ribosome-dependent activity of G factor and translocation of peptidyl-tRNA.

Suppresses nitric oxide lysis of pancreatic islet cells; inhibits protein synthesis in prokaryotes.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 + P330 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves