For an inhibitor for beta oxidation, the following products may be of interest:
•E1905 (+)-Etomoxir sodium salt hydrate
•5.09455 InSolution Etomoxir
•M5199 Meldonium dihydrate
E1905
(+)-Etomoxir sodium salt hydrate
≥98% (HPLC), powder, CPT-1 inhibitor
Synonym(s):
R(+)-2-[6-(4-Chlorophenoxy)hexyl]-oxirane-2-carboxylic acid sodium salt hydrate
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 5 mg | Available to ship TODAYfromMILWAUKEE | $233.00 | |
| 25 mg | Available to ship TODAYfromMILWAUKEE | $800.00 |
About This Item
Empirical Formula (Hill Notation):
C15H18ClO4 · Na · H2O
CAS Number:
Molecular Weight:
338.76
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Product Name
(+)-Etomoxir sodium salt hydrate, ≥98% (HPLC), powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white
solubility
H2O: freely soluble
storage temp.
2-8°C
SMILES string
O.[Na+].[O-]C(=O)[C@@]2(CCCCCCOc1ccc(Cl)cc1)CO2
InChI
1S/C15H19ClO4.Na.H2O/c16-12-5-7-13(8-6-12)19-10-4-2-1-3-9-15(11-20-15)14(17)18;;/h5-8H,1-4,9-11H2,(H,17,18);;1H2/q;+1;/p-1/t15-;;/m1../s1
InChI key
WENJLJJSJDAJDN-QCUBGVIVSA-M
General description
(+)-Etomoxir sodium salt hydrate belongs to oxirane carboxylic acid group of compounds and mediates metabolic channeling of fatty acid precursors. It favors oxidative stress in T cells and prevents T cell differentiation. It inhibits fatty acid oxidation and promotes hunger and food intake.[1] Etomoxir impairs myeloid-derived suppressor cells mediated tumor and could have potential therapeutic potential.
Application
(+)-Etomoxir sodium salt hydrate has been used as an inhibitor of carnitine palmitoyltransferase 1 (CPT-1) in breast tumor cell lines and mice tumor. It has also been used as an inhibitor of fatty acid oxidation in human primary prostate epithelial cells and lymphocytes.
Biochem/physiol Actions
Irreversible O-carnitine palmitoyltransferase-1 (CPT-1) inhibitor; PPARα activator
Packaging
Store tightly sealed, protected from exposure to light
1 of 1
This Item | |||
|---|---|---|---|
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| form powder | form solid | form powder | form solid |
| Quality Level 100 | Quality Level 100 | Quality Level 200 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. room temp | storage temp. room temp |
| solubility H2O: freely soluble | solubility DMSO: 50 mg/mL (or water) | solubility DMSO: 5 mg/mL, clear | solubility DMSO: 10 mg/mL, clear |
| color white | color white | color light yellow to dark yellow | color white to off-white |
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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Articles
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| E1905-5MG | 04061833602324 |
| E1905-25MG | 04061833602317 |
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