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C4650

Cholestyramine resin

Synonym(s):

Colestyramine

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25 g

Available to ship TODAYfromMILWAUKEE

$252.00
100 g

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$622.00
250 g

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$1,280.00

About This Item

CAS Number:
11041-12-6
UNSPSC Code:
23151817
EC Number:
234-270-8
NACRES:
NA.56
MDL number:
MFCD00130784

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assay

13-17% chloride basis (dried substance)

Quality Segment

200

form

powder

technique(s)

activity assay: suitable

matrix

polystyrene/divinylbenzene

pH

4—6

capacity

~1.0 meq/g(dry)

Application

Cholestyramine resin has been used:
  • as a diet supplement to study the bile acid pool size and fecal bile acid output in mice
  • to alter the bile acid (BA) levels and study its effect on liver fibrosis development in wild type (WT), fibroblast growth factor 15 (Fgf15)−/−, and Fgf15 transgenic (TG) mice
  • in in vitro digestion process to study the capacity of the fractions for binding bile acid (BA)

Cholestyramine resin is used in protein chromatography, ion exchange chromatography and anion exchange media. Cholestyramine has been used to study the relief of postcholecystectomy diarrhea, the management of intractable cholestatic pruritus and obesity.

Biochem/physiol Actions

Cholestyramine is a cationic exchange resin polymer. This resin is a bile acid sequestrant that interchanges chloride anions for bile acids of the small intestine lumen, leading to excretion of bile acids in the feces and reduced levels of serum bile acid. Cholestyramine is used to treat primary hypercholesterolemia. The resin induces dose-dependent reduction of low-density lipid (LDL) cholesterol. It ameliorates the risk of coronary artery disease.

Other Notes

Quartenary ammonium functional groups attached to cross-linked polystyrene

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This Item
113300444425428612
Cholestyramine resin

Sigma-Aldrich

C4650

Cholestyramine resin

USP

USP

1133004

Cholestyramine resin

Amberlite™ HPR4811 Cl Anion Exchange Resin Anion Exchange Resin

Sigma-Aldrich

44425

Amberlite™ HPR4811 Cl Anion Exchange Resin

AmberChrom™ 1X4 chloride form 20-50 mesh, Anion Exchange Resin

Supelco

428612

AmberChrom™ 1X4 chloride form

matrix

polystyrene/divinylbenzene

matrix

-

matrix

styrene-divinylbenzene (gel)

matrix

styrene-divinylbenzene (gel)

form

powder

form

-

form

solid

form

beads

technique(s)

activity assay: suitable

technique(s)

-

technique(s)

-

technique(s)

LPLC: suitable

capacity

~1.0 meq/g(dry)

capacity

-

capacity

1.3 meq/mL by wetted bed volume

capacity

1.0 meq/mL capacity

Quality Level

200

Quality Level

-

Quality Level

-

Quality Level

100

assay

13-17% chloride basis (dried substance)

assay

-

assay

-

assay

-

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Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
BCCP2660
BCCN0514
BCBW0881
BCBT9715
1425455

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A R Bolier et al.
Acta gastro-enterologica Belgica, 75(4), 399-404 (2013-02-14)
Pruritus can be the dominant symptom of cholestatic liver disease but is difficult to treat since unraveling its pathophysiology is a great challenge. Serum autotaxin activity correlates with pruritus intensity, but its causal relationship, expression pattern and exact mode of
Guodong Li et al.
American journal of physiology. Gastrointestinal and liver physiology, 305(11), G829-G837 (2013-10-05)
Farnesoid X receptor (FXR, Nr1h4) is a ligand-activated transcription factor belonging to the nuclear receptor superfamily. FXR is essential in maintaining bile acid (BA) homeostasis, and FXR(-/-) mice develop cholestasis, inflammation, and spontaneous liver tumors. The signal transducer and activator
Guillermo Rodríguez-Gutiérrez et al.
Journal of agricultural and food chemistry, 62(36), 8973-8981 (2014-08-21)
A process based on a steam explosion pretreatment and alkali solution post-treatment was applied to fractionate olive stones (whole and fragmented, without seeds) and olive cake into their main constitutive polymers of cellulose (C), hemicelluloses (H), and lignin (L) under
View All Related Papers

Global Trade Item Number

SKUGTIN
C4650-250G04061833662397
C4650-25G04061833492413
C4650-100G04061833434642

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