S8409
Superoxide Dismutase from bovine liver
ammonium sulfate suspension, 2,000-6,000 units/mg protein (biuret)
Synonyme(s) :
SOD, Superoxide: superoxide oxidoreductase
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About This Item
Produits recommandés
Forme
ammonium sulfate suspension
Niveau de qualité
Activité spécifique
2,000-6,000 units/mg protein (biuret)
Poids mol.
32.5 kDa
Numéro d'accès UniProt
Température de stockage
2-8°C
Informations sur le gène
cow ... SOD1(281495)
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Description générale
Research area: Cell Signaling
Superoxide dismutases are a group of low molecular weight metalloproteins present in all aerobic cells of plants, animals, and micro-organisms. They provide protection against damaging reactions with the superoxide radical anion (O2-) by catalyzing its disproportionation into oxygen and hydrogen peroxide.
Superoxide dismutases are a group of low molecular weight metalloproteins present in all aerobic cells of plants, animals, and micro-organisms. They provide protection against damaging reactions with the superoxide radical anion (O2-) by catalyzing its disproportionation into oxygen and hydrogen peroxide.
Application
Superoxide Dismutase from bovine liver has been used:
- for measuring mitochondrial hydrogen peroxide production in skeletal muscle
- as a positive control in Cu(II) binding stability assay
- as a positive control in superoxide dismutase assay
- in a study to assess the inactivation of endothelial-derived relaxing factor by oxidized lipoproteins.
- in a study to investigate the role of hydrogen peroxide in the cytotoxicity of the xanthine/xanthine oxidase system.
Actions biochimiques/physiologiques
Superoxide Dismutase catalyzes the dismutation of superoxide radicals to hydrogen peroxide and molecular oxygen. It plays a critical role in the defense of cells against the toxic effects of oxygen radicals. It competes with nitric oxide (NO) for superoxide anion (which reacts with NO to form peroxynitrite), thereby SOD promotes the activity of NO. SOD has also been shown to suppress apoptosis in cultured rat ovarian follicles, neural cell lines, and transgenic mice.
Définition de l'unité
One unit will inhibit reduction of cytochrome c by 50% in a coupled system with xanthine oxidase at pH 7.8 at 25 °C in a 3.0 mL reaction volume. Xanthine oxidase concentration should produce an initial ΔA550 of 0.025 ± 0.005 per min.
Forme physique
Suspension in 3.8 M (NH4)2SO4, pH 7.0
Remarque sur l'analyse
For assay method, see McCord, J.M. and Fridovich,I., J. Biol. Chem., 244, 6049 (1969).
Mention d'avertissement
Danger
Mentions de danger
Conseils de prudence
Classification des risques
Resp. Sens. 1
Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Équipement de protection individuelle
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Certificats d'analyse (COA)
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