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Key Documents

S7446

Sigma-Aldrich

Superoxide Dismutase from bovine erythrocytes

BioUltra, lyophilized powder, ≥4,500 units/mg protein, ≥97% (SDS-PAGE)

Synonyme(s) :

SOD, Superoxide: superoxide oxidoreductase

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About This Item

Numéro CAS:
Numéro de classification (Commission des enzymes):
Numéro CE :
Numéro MDL:
Code UNSPSC :
12352204
Nomenclature NACRES :
NA.54

Gamme de produits

BioUltra

Pureté

≥97% (SDS-PAGE)

Forme

lyophilized powder

Activité spécifique

≥4,500 units/mg protein

Poids mol.

32.5 kDa

Composition

Protein, ≥95% biuret

Maladie(s) pertinente(s)

arthritis

Température de stockage

−20°C

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Description générale

Research area: Cell signaling. Superoxide Dismutase (SOD) is found in allaerobic cells of the animals, plants, and microorganisms. It is a low molecularweight protein that exists as three different forms such as manganese SOD,copper–zinc SOD, and extracellular SOD.

Application

Superoxide Dismutase from bovine erythrocytes has been used in a study to assess activity parameters in adjuvant-induced arthritis. Superoxide Dismutase from bovine erythrocytes has also been used in a study to simplify the process of purifying superoxide dismutases using charge-controlled hydrophobic chromatography on 10-carboxydecyl Sepharose. It has also been used as a standard in SOD assay in mice liver andkidney samples.

Actions biochimiques/physiologiques

Superoxide Dismutase from bovine erythrocytes catalyzes the dismutation of superoxide radicals to hydrogen peroxide and molecular oxygen. It serves as an antioxidant and plays a critical role in the defense of cells against the toxic effects of oxygen radicals. Competes with nitric oxide (NO) for superoxide anion (which reacts with NO to form peroxynitrite), thereby SOD promotes the activity of NO. SOD has also been shown to suppress apoptosis in cultured rat ovarian follicles, neural cell lines, and transgenic mice.

Définition de l'unité

One unit will inhibit reduction of cytochrome c by 50% in a coupled system with xanthine oxidase at pH 7.8 at 25 °C in a 3.0 mL reaction volume. Xanthine oxidase concentration should produce an initial ΔA550 of 0.025 ± 0.005 per min.

Pictogrammes

Health hazard

Mention d'avertissement

Danger

Mentions de danger

Conseils de prudence

Classification des risques

Resp. Sens. 1

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)


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Consulter la Bibliothèque de documents

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Medeiros F, et al.
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A García-González et al.
Archives of medical research, 30(2), 132-137 (1999-06-18)
The purpose of this work was to evaluate the effect of superoxide dismutase (SOD) on primary swelling, lipoperoxidation, body thymus, and spleen weight in the adjuvant-induced arthritis (AIA) model in rats. Orally and intraperitoneally administered SOD (100 U/kg) from bovine
Characterisation by EPR spectroscopy of the co-ordination environment of copper in superoxide dismutase from horseradish (Armoracia rusticana Gaertn.)
Palivan, CG and Palivan, H
Proceedings of the Royal Society of Edinburgh. Section B: Biology, 102, 273-277 (1994)
Purification of pro- and eukaryotic superoxide dismutases by charge-controlled hydrophobic chromatography
Grunow, M. and W. Schopp
Journal of Chromatography A, 590, 247-253 (1992)
Lu Miao et al.
Free radical biology & medicine, 47(4), 344-356 (2009-05-30)
Numerous short-lived and highly reactive oxygen species (ROS) such as superoxide (O2(.-)), hydroxyl radical, and hydrogen peroxide are continuously generated in vivo. Depending upon concentration, location, and intracellular conditions, ROS can cause toxicity or act as signaling molecules. The cellular

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