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D0540

Sigma-Aldrich

DNQX

≥98% (TLC)

Synonyme(s) :

6,7-Dinitroquinoxaline-2,3(1H,4H)-dione

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About This Item

Formule empirique (notation de Hill):
C8H4N4O6
Numéro CAS:
2379-57-9
Poids moléculaire :
252.14
Numéro MDL:
MFCD00069257
Code UNSPSC :
51111800
ID de substance PubChem :
24277973
Nomenclature NACRES :
NA.77

Niveau de qualité

200

Pureté

≥98% (TLC)

Forme

powder

Chaîne SMILES 

[O-][N+](=O)c1cc2NC(=O)C(=O)Nc2cc1[N+]([O-])=O

InChI

1S/C8H4N4O6/c13-7-8(14)10-4-2-6(12(17)18)5(11(15)16)1-3(4)9-7/h1-2H,(H,9,13)(H,10,14)

Clé InChI

RWVIMCIPOAXUDG-UHFFFAOYSA-N

Informations sur le gène

human ... GRIA1(2890) , GRIA2(2891) , GRIK1(2897) , GRIK2(2898) , GRIK3(2899) , GRIK4(2900) , GRIK5(2901)
mouse ... Gria1(14799)
rat ... Gria1(50592) , Grik1(29559) , Grik4(24406) , Grin2a(24409)

Application

DNQX has been used to block N-Methyl-D-aspartic acid (NMDA) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in various experiments.

Actions biochimiques/physiologiques

DNQX is a quinoxaline derivative.
A competitive kainate, quisqualate (non-NMDA) glutamate receptor antagonist.

Caractéristiques et avantages

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Focal activation of neuronal circuits induced by microstimulation in the visual cortex
Tanaka Y, et al.
Journal of Neural Engineering, 16(3), 036007-036007 (2019)
J Waider et al.
Translational psychiatry, 7(10), e1246-e1246 (2017-10-04)
Multiple lines of evidence implicate brain serotonin (5-hydroxytryptamine; 5-HT) system dysfunction in the pathophysiology of stressor-related and anxiety disorders. Here we investigate the influence of constitutively deficient 5-HT synthesis on stressor-related anxiety-like behaviors using Tryptophan hydroxylase 2 (Tph2) mutant mice.
Rei Yamada et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(9), 3927-3938 (2013-03-01)
Neurons in the nucleus laminaris (NL) of birds detect the coincidence of binaural excitatory inputs from the nucleus magnocellularis (NM) on both sides and process the interaural time differences (ITDs) for sound localization. Sustained inhibition from the superior olivary nucleus
The mouse pulvinar nucleus links the lateral extrastriate cortex, striatum, and amygdala
Zhou N, et al.
The Journal of Neuroscience, 38(2), 347-362 (2018)
James M Otis et al.
Neuron, 103(3), 423-431 (2019-06-15)
The paraventricular thalamus (PVT) is an interface for brain reward circuits, with input signals arising from structures, such as prefrontal cortex and hypothalamus, that are broadcast to downstream limbic targets. However, the precise synaptic connectivity, activity, and function of PVT circuitry
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