178810

Tetrahydrofurane

≥99.0%, contains 250 ppm BHT as inhibitor, ReagentPlus^®

• Synonyme(s) : Oxolane, Oxyde de butylène, Oxyde de tétraméthylène
• Formule empirique (notation de Hill): C₄H₈O
• Numéro CAS: 109-99-9
• Poids moléculaire : 72.11
• Numéro Beilstein : 102391
• Numéro CE : 203-726-8
• Numéro MDL: MFCD00005356
• Code UNSPSC : 12191501
• ID de substance PubChem : 329751576
• Nomenclature NACRES : NA.21

Propriétés

• product name: Tetrahydrofurane, ReagentPlus^®, ≥99.0%, contains 250 ppm BHT as inhibitor
• Densité de vapeur: 2.5 (vs air)
• Niveau de qualité: 100
• Pression de vapeur: 114 mmHg ( 15 °C); 143 mmHg ( 20 °C)
• Gamme de produits: ReagentPlus^®
• Pureté: ≥99.0%
• Forme: liquid
• Température d'inflammation spontanée: 610 °F
• Contient: 250 ppm BHT as inhibitor
• Limite d'explosivité: 1.8-11.8 %
• Indice de réfraction: n20/D 1.407 (lit.)
• pH: ~7
• Point d'ébullition: 65-67 °C (lit.)
• Pf: −108 °C (lit.)
• Densité: 0.889 g/mL at 25 °C (lit.)
• Chaîne SMILES: C1CCOC1
• InChI: 1S/C4H8O/c1-2-4-5-3-1/h1-4H2
• Clé InChI: WYURNTSHIVDZCO-UHFFFAOYSA-N

Description

Description générale

Tetrahydrofuran (THF) is a saturated cyclic ether mainly used as an organic solvent. On long term storage it forms organic peroxides. This process can be suppressed by adding butylated hydroxytoluene (BHT) as a stabilizer. BHT removes the free radicals required for the peroxide formation. THF constitutes the key fragment of various natural products (polyether antibiotics). THF can form a double hydrate with hydrogen sulfide. Crystal structure of this double hydrate has been investigated by three-dimensional single-crystal studies. Butane-1,4-diol is formed as an intermediate during the synthesis of THF. Hot THF is useful for the dissolution of polyvinylidene chloride (PVDV).

Application

Tetrahydrofuran may be used for the dissolution of poly-ε-caprolactone (PCL) and 1,3-diaminopentane, during the preparation of poly-ε-caprolactone (PCL)-hydroxyapatite (HA) scaffolds and acrylate-terminated poly(5-amino-1-pentanol-co-1,4-butanediol diacrylate) (C32)- 1,3-diaminopentane (117) polymer, respectively.

Autres remarques

For information on tetrahydrofuran miscibility, please visit the following link:
Tetrahydrofuran Miscibility/Immiscibility Table

Greener alternatives are available for many THF applications, 2-Methyltetrahydrofuran (155810) and Cyclopentyl methyl ether (675989)

Read more about THF alternatives:
2-Methyltetrahydroun (2-MeTHF): A biomass-Derived solvent with Broad Applications in Organic Chemistry

The toxicological assessment of cyclopentyl methyl ether (CPME) as a green solvent

Informations légales

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Pictogrammes: GHS02,GHS08,GHS07
• Mention d'avertissement: Danger
• Mentions de danger: H225,H302,H319,H335,H336,H351
• Conseils de prudence: P202 - P210 - P233 - P301 + P312 - P305 + P351 + P338 - P308 + P313
• Classification des risques: Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3
• Organes cibles: Central nervous system, Respiratory system
• Risques supp: EUH019
• Code de la classe de stockage: 3 - Flammable liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): -6.2 °F - closed cup
• Point d'éclair (°C): -21.2 °C - closed cup