Regarding KITALYSIS-CN-1KT KitAlysis™ High-Throughput Buchwald-Hartwig Amination Reaction Screening Kit-Pack of 4, there are links to specific usage instructions posted on this page.
https://www.sigmaaldrich.com/product/aldrich/kitalysiscn#product-documentation
These describe reactions carried out at various temperatures (depending on the substrate used), e.g. 60 - 80 degrees C, controlled by the use of a heating bath.
KITALYSIS-CN
KitAlysis™ High-Throughput Buchwald-Hartwig Amination Reaction Screening Kit-Pack of 4
Synonyme(s) :
Amination Screening Kit, Buchwald-Hartwig Amination
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About This Item
Code UNSPSC :
12161503
Nomenclature NACRES :
NA.22
Le tarif et la disponibilité ne sont pas disponibles actuellement.
Produits recommandés
Capacité de réaction
reaction type: Buchwald-Hartwig Amination
reaction type: Buchwald-Hartwig Cross Coupling Reaction
reaction type: Cross Couplings
Pertinence de la réaction
reagent type: catalyst
core: palladium
Température de stockage
room temp
Description générale
The KitAlysis™ High Throughput Buchwald–Hartwig Amination Reaction Screening Kit enables chemists to quickly and efficiently screen Buchwald–Hartwig C–N cross-coupling reaction conditions. Quick identification of optimal conditions allows faster scale-up of the synthetic reaction. All required chemicals come pre-weighed for ease of use. A step-by-step user guide and experimental excel sheets are available for download to facilitate the process.
Application
There are four possible screens that can be run based upon the user’s substrates. Step-by-step user guides and a downloadable experimental excel sheets for each screen is provided in the below hyperlinks.
Two Solvents, Weak Base (Cs2CO3)
Download the experimental excel file here
Two Solvents, Strong Base (NaOt-Bu)
Download the experimental excel file here
One Solvent (Dioxane), Two Bases
Download the experimental excel file here
One Solvent (DMAc), Two Bases
Download the experimental excel file here
Each kit contains 4 screening sets that contain the following:
Each customizable screening kit contains
Best when used with KitAlysis Benchtop Inertion Box and 24-well Reaction Block (sold separately).
Two Solvents, Weak Base (Cs2CO3)
Download the experimental excel file here
Two Solvents, Strong Base (NaOt-Bu)
Download the experimental excel file here
One Solvent (Dioxane), Two Bases
Download the experimental excel file here
One Solvent (DMAc), Two Bases
Download the experimental excel file here
Each kit contains 4 screening sets that contain the following:
Each customizable screening kit contains
- 12 X 2 pre-weighed catalysts (1 μmol) in individual microvials with magnetic stir bars
- 2 bases (NaOt-Bu and Cs2CO3)
- 2 degassed anhydrous solvents (dioxane and DMAc) in ampules
- 2 substrate reaction vials with stir bars
- 1 internal standard
- 4 reaction block replacement films
Best when used with KitAlysis Benchtop Inertion Box and 24-well Reaction Block (sold separately).
Caractéristiques et avantages
- Designed and tested by synthetic chemists
- Easily run 24-microscale reaction in parallel
- 10 μmol reactions with 1 μmol catalyst, 3 equiv. base, 0.1 M concentration
- Customizable Excel Template for quick calculations and easy incorporation into electronic laboratory notebooks
Informations légales
KitAlysis is a trademark of Sigma-Aldrich Co. LLC
Composants de kit seuls
Réf. du produit
Description
- SnapIT Ampule Opener, Regular, for 1-2ml, 5-10ml, 10-15ml ampoules 1 EA
Composants de kit également disponibles séparément
Réf. du produit
Description
FDS
- 900634N,N-Dimethylacetamide, anhydrous, ZerO2®, 99.8% 8 mLFDS
- 9006401,4-Dioxane, anhydrous, ZerO2®, 99.8% 8 mLFDS
- 702706Sodium tert-butoxide solution, 2 M in THF, ZerO2® 4 mLFDS
- 747130Josiphos SL-J009-1 Pd G3 5 µmolFDS
- 753009SPhos Pd G2 5 µmolFDS
- 753246RuPhos Pd G2 5 µmolFDS
- 756482P(t-Bu)3 Pd G2 5 µmolFDS
Afficher tout (15)
En option
Réf. du produit
Description
Tarif
Produit(s) apparenté(s)
Réf. du produit
Description
Tarif
Mention d'avertissement
Danger
Mentions de danger
Classification des risques
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B - Eye Dam. 1 - Repr. 1B - Self-heat. 1 - Skin Corr. 1B - STOT RE 2 Oral - STOT SE 3
Organes cibles
Central nervous system, Kidney,Adrenal gland,Testes, Respiratory system
Risques supp
Code de la classe de stockage
4.2 - Pyrophoric and self-heating hazardous materials
Point d'éclair (°F)
-4.0 °F - closed cup
Point d'éclair (°C)
-20 °C - closed cup
Faites votre choix parmi les versions les plus récentes :
Certificats d'analyse (COA)
Lot/Batch Number
It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.
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Les clients ont également consulté
High-Throughput Experimentation in Catalysis and Materials Science.
Gordillo A, et al. et al.
Ullmann's Encyclopedia of Industrial Chemistry (2014)
Scientist-Led High-Throughput Experimentation (HTE) and Its Utility in Academia and Industry.
Schmink JR, et al.
Aldrichimica Acta, 46, 71-80 (2013)
Karl D Collins et al.
Nature chemistry, 6(10), 859-871 (2014-09-23)
New organic reactivity has often been discovered by happenstance. Several recent research efforts have attempted to leverage this to discover new reactions. In this Review, we attempt to unify reported approaches to reaction discovery on the basis of the practical
Spencer D Dreher et al.
Journal of the American Chemical Society, 130(29), 9257-9259 (2008-06-28)
Microscale parallel experimentation was used to discover three catalyst systems capable of coupling secondary organotrifluoroborates with sterically and electronically demanding aryl chlorides and bromides. The ensuing results represent the first comprehensive study of alkylboron coupling to aryl chlorides and, in
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Good morning Iwould have a question regarding the KitAlysis™ High-Throughput Buchwald-Hartwig Amination Reaction Screening Kit-Pack of 4. Is It possible to work at various temperatures or it's only thinked for the RT?
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