mAbs Characterization & Quality Control
The key for ensuring drug safety and efficacy
Characterization and quality control of monoclonal antibodies (mAbs) is essential to ensure their efficacy and safety. Analytical techniques, like HPLC and mass spectrometry, are vital to assess various properties, such as aggregation, charge variants, and post-translational modifications (PTMs). Our extensive selection of products supports the detailed analysis and evaluation of mAbs to maintain quality and effectiveness.
Titer Determination of Monoclonal Antibodies
In the characterization and analysis of monoclonal antibodies (mAbs), titer determination measures the concentration or potency of mAbs in a sample, which is important for maintaining the efficacy and safety of therapeutic mAbs. Protein A affinity chromatography is a powerful tool for the selective capture and purification of mAbs to ensure the consistency and quality of the final product.
Our high-performance liquid chromatography (HPLC) columns are engineered for protein analysis in titer determination of mAbs. Chromolith® WP 300 Protein A HPLC column is specifically designed to monitor monoclonal antibody titer and yield determination from cell-culture supernatants. This procedure optimizes the monoclonal antibody titer and determines the ideal time for harvesting the monoclonal antibody products.
Our reliable mobile-phase buffers can be used to carry the sample through the HPLC column to control the separation and elution of mAbs and impurities during the analysis. Choose from a wide range of HPLC grade buffers to mitigate pH fluctuation in the mobile phase of HPLC.
Use our highest grade of solvents in mAb production to minimize the risk of impurities. Our high-purity solvents undergo rigorous purification processes and are tested for premium quality to ensure they meet your specifications.
Related Categories
Monitor mAb titer and yield determination from cell-culture supernatants for ideal harvesting.
Choose HPLC-grade buffers with the right purity, compatibility, solubility and strength.
Use our highest grade of solvents in mAb production to minimize the risk of impurities.
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- Brochure: Rapid and Robust Antibody Quantitation - Chromolith® WP 300 Protein A HPLC Columns
The Chromolith® WP 300 Protein A HPLC column is designed to monitor monoclonal antibody titer and yield determination from cell-culture supernatants. This analytical scale procedure helps to optimize the titer of monoclonal antibody for the optimal time for harvest of the monoclonal antibody products.
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The new, upgraded Milliflex® Rapid System 2.0, while still based on the same proven ATP bioluminescence technology offering the accustomed performance, has been equipped with a range of new features.
Explore a simple and high throughput method for the quantitation of monoclonal antibodies and proteins in human and animal serum.
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