Key Documents

Sibutramine hydrochloride monohydrate

Name: Sibutramine hydrochloride monohydrate
Brand: SIGMA

≥98% (HPLC), solid

Synonym(s):

1-(4-Chlorophenyl)-N,N-dimethyl-alpha-(2-methylpropyl)cyclobutanemethanamine hydrochloride monohydrate, Meridia, Reductil

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About This Item

Empirical Formula (Hill Notation):

C₁₇H₂₆ClN · HCl

CAS Number:

84485-00-7

Molecular Weight:

316.31

NACRES:

NA.77

PubChem Substance ID:

329824638

UNSPSC Code:

12352116

MDL number:

MFCD04039806

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

Storage condition:

desiccated

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Properties

Quality Level

100

assay

≥98% (HPLC)

form

solid

drug control

USDEA Schedule IV

storage condition

desiccated

color

white

solubility

DMSO: >30 mg/mL, H₂O: insoluble

originator

Abbott

storage temp.

room temp

SMILES string

O.Cl.CC(C)CC(N(C)C)C1(CCC1)c2ccc(Cl)cc2

InChI

1S/C17H26ClN.ClH.H2O/c1-13(2)12-16(19(3)4)17(10-5-11-17)14-6-8-15(18)9-7-14;;/h6-9,13,16H,5,10-12H2,1-4H3;1H;1H2

InChI key

KFNNPQDSPLWLCX-UHFFFAOYSA-N

Gene Information

human ... SLC6A2(6530), SLC6A3(6531), SLC6A4(6532)

Description

Application

Sibutramine hydrochloride monohydrate was used as standard to screen dietary supplements for sibutramine using ion mobility spectrometer.¹

Biochem/physiol Actions

Sibutramine is a serotonin and noradrenaline reuptake inhibitor (SNRI).

Sibutramine is a serotonin and noradrenaline reuptake inhibitor (SNRI). It is an antiobesity drug, which decreases calorie intake and increases energy expanditure. Sibutramine antagonizes MPTP-induced dopamine depletion in mouse brain.

Features and Benefits

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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This Item	F112	SML0608	SML0276
Sigma-Aldrich S9944 Sibutramine hydrochloride monohydrate	Sigma-Aldrich F112 (+)-Fenfluramine hydrochloride	Sigma-Aldrich SML0608 A-412997 dihydrochloride	Sigma-Aldrich SML0276 BD 1063 dihydrochloride
form solid	form powder	form powder	form powder
assay ≥98% (HPLC)	assay -	assay ≥98% (HPLC)	assay ≥98% (HPLC)
drug control USDEA Schedule IV	drug control USDEA Schedule IV	drug control -	drug control -
Quality Level 100	Quality Level 200	Quality Level 100	Quality Level 100
storage temp. room temp	storage temp. room temp	storage temp. room temp	storage temp. room temp
solubility DMSO: >30 mg/mL, H₂O: insoluble	solubility H₂O: soluble 10 mg/mL	solubility H₂O: 20 mg/mL, clear	solubility H₂O: >15 mg/mL

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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AVN-492, A Novel Highly Selective 5-HT6R Antagonist: Preclinical Evaluation.

Alexandre V Ivachtchenko et al.

Journal of Alzheimer's disease : JAD, 58(4), 1043-1063 (2017-05-28)

Discovery of 5-HT6 receptor subtype and its exclusive localization within the central nervous system led to extensive investigations of its role in Alzheimer's disease, schizophrenia, and obesity. In the present study, we present preclinical evaluation of a novel highly-potent and

Adsorption and determination of sibutramine in illegal slimming product using porous graphene ink-modified electrode.

Jenjira Saichanapan et al.

Talanta, 212, 120788-120788 (2020-03-03)

This work presents a new material, i.e., a porous graphene ink to modify on the GCE surface (PGr-ink/GCE) to improve sensitivity by increasing the surface area of the electrode for the electrochemical determination of sibutramine. The surface characterization and electrochemical

Using a portable ion mobility spectrometer to screen dietary supplements for sibutramine.

Jamie D Dunn et al.

Journal of pharmaceutical and biomedical analysis, 54(3), 469-474 (2010-10-14)

In response to recent incidents of undeclared sibutramine, an appetite suppressant found in dietary supplements, we developed a method to detect sibutramine using hand-held ion mobility spectrometers with an analysis time of 15 s. Ion mobility spectrometry is a high-throughput

View All Related Papers

Global Trade Item Number

SKU	GTIN
S9944-50MG	04061832084787
S9944-25MG	04061832084770

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