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L9507

Lactoferrin from bovine milk

≥85% (SDS-PAGE)

Synonym(s):

Bos d LF, Lactotransferrin

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About This Item

CAS Number:
936541-36-5
UNSPSC Code:
12352202
NACRES:
NA.61
MDL number:
MFCD00131481
Form:
powder
Assay:
≥85% (SDS-PAGE)
Biological source:
bovine milk
Mol wt:
~87 kDa
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biological source

bovine milk

Quality Level

200

assay

≥85% (SDS-PAGE)

form

powder

mol wt

~87 kDa

technique(s)

fractionation: suitable

solubility

H2O: soluble 10 mg/mL

UniProt accession no.

P24627

storage temp.

2-8°C

Gene Information

cow ... LTF(280846)

Application

Lactoferrin was used in the fractionation of lactoperoxidase and lactoferrin from bovine whey using a cation exchange membrane. It was used in the determination of lactoferrin and immunoglobulin G in animal milks by new immunosensors.[1]

Biochem/physiol Actions

Lactoferrin is an iron binding protein. It is structurally similar to transferrin, the plasma iron transport protein; but lactoferrin has a much higher affinity for iron (250 fold). It is very abundant in colostrum and small amounts can also be found in tears, saliva, mucous secretions and in the secondary granules of neutrophils. It is made by mucosal epithelium and neutrophils and is released by these cells in response to inflammatory stimuli. Bacterial growth is inhibited by its ability to sequester iron and also permeabilize bacterial cell walls by binding to lipopolysaccharides through its N-terminus. Lactoferrin can inhibit viral infection by binding tightly to the viral envelope protein. This prevents cell-virus fusion by blocking the binding domain. Lactoferrin appears to activate host defense systems in part by stimulating the release of interleukin-8, a neutrophil activator. It may also be involved in antibody and interleukin synthesis, lymphocyte proliferation and complement activation.

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This Item
6132661327L4894
Lactoferrin from bovine milk ≥85% (SDS-PAGE)

Sigma-Aldrich

L9507

Lactoferrin from bovine milk

Lactoferrin from human milk ~80% (GE)

Sigma-Aldrich

61326

Lactoferrin from human milk

Lactoferrin from human milk iron-saturated, ≥85% (GE)

Sigma-Aldrich

61327

Lactoferrin from human milk

Lactoferrin from human milk powder, BioReagent, suitable for cell culture

Sigma-Aldrich

L4894

Lactoferrin from human milk

technique(s)

fractionation: suitable

technique(s)

-

technique(s)

-

technique(s)

cell culture | mammalian: suitable

assay

≥85% (SDS-PAGE)

assay

~80% (GE)

assay

≥85% (GE)

assay

≥85% (SDS-PAGE)

biological source

bovine milk

biological source

human milk

biological source

human milk

biological source

-

form

powder

form

solid

form

solid

form

powder

mol wt

~87 kDa

mol wt

82.4 kDa

mol wt

82.4 kDa

mol wt

82.4 kDa

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000498841
0000498841
0000494388
0000494387
0000494387

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Qianqian Yao et al.
PeerJ, 9, e11072-e11072 (2021-06-17)
Colorectal cancer is a common cause of death with few available therapeutic strategies, and the preventative complexes in adjunctive therapy are urgently needed. Increasing evidences have shown that natural ingredients, including lactoferrin, oleic acid, docosahexaenoic acid (DHA) and linolenic acid
Mona M Abdel-Wahab et al.
Fish & shellfish immunology, 111, 160-169 (2021-02-09)
The present study was carried out to investigate the effects of dietary bovine lactoferrin (BLF) or chitosan nanoparticles (CHN) alone or in combinations on serum biochemical indices, antioxidative capacity, transcriptomic responses, non-specific immunity, and resistance of Nile tilapia (Oreochromis niloticus)
O Oyen et al.
FEBS letters, 229(2), 391-394 (1988-03-14)
Cyclic AMP (cAMP) and its action by way of cAMP-dependent protein kinase is important for sperm motility. Previous studies on germ cells have demonstrated a selective decrease in the amount of type I cAMP-dependent protein kinase during spermatid development, and
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Global Trade Item Number

SKUGTIN
L9507-10MG04061833966693
L9507-50MG04061835557646

Questions

  1. Is this product dissolvable in plant based oils?

    1 answer

    1. This product has not been tested for solubility in plant oils. However, it can be solubilized in water and aqueous solutions, 10 mg/mL of water and 1 mg/mL of PBS, respectively. A brief search of the literature shows that oil emulsions have been frequently studied.

      See the link below for a publication that may be helpful.
      https://pubs.acs.org/doi/full/10.1021/jf9809939

      Helpful?

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