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I9409

Monoclonal Anti-Insulin-like Growth Factor-I antibody produced in hamster

clone 126002, purified immunoglobulin, lyophilized powder

Synonym(s):

Anti-IGF-I

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About This Item

UNSPSC Code:
51111800
NACRES:
NA.41
MDL number:
MFCD00162566
Conjugate:
unconjugated
Clone:
126002, monoclonal
Application:
ELISA (c), Neutral, WB
Citations:
3
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biological source

hamster

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

126002, monoclonal

form

lyophilized powder

species reactivity

mouse

technique(s)

capture ELISA: 2-8 μg/mL, neutralization: suitable, western blot: 1-2 μg/mL

isotype

IgG1

UniProt accession no.

P05017

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

mouse ... Igf1(16000)

General description

Insulin-like Growth Factor-I (also known as somatomedinC and somatomedin A) and insulin-like growth factor-II(IGF-II) belong to the family of insulin-like growthfactors, which are structurally homologous to proinsulin.Mature IGF-I and IGF-II are h

Immunogen

purified, E. coli-derived recombinant mouse insulin-like growth factor-I.

Biochem/physiol Actions

Insulin-like growth factor -1 shares structural homology with proinsulin and is mainly produced by liver. IGF-1 acts via specific receptor, IGF-1R, a heterodimeric tyrosine kinase receptor that signals to various second messenger pathways such as MAPK, Raf/Ras and PI3K cascades. The effects of IGF-1R signaling are important at many developmental levels from cells to organ to organism, growth, differentiation, anti-apoptosis, proliferation and transformation.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Monoclonal Anti-Insulin-like Growth Factor-I antibody produced in hamster clone 126002, purified immunoglobulin, lyophilized powder

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Monoclonal Anti-Insulin-like Growth Factor-I antibody produced in hamster

Monoclonal Anti-Insulin-Like Growth Factor Binding Protein-1 antibody produced in mouse clone 33627.11, purified immunoglobulin, lyophilized powder

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Monoclonal Anti-Insulin-Like Growth Factor Binding Protein-1 antibody produced in mouse

Monoclonal Anti-Hepatocyte Growth Factor antibody produced in mouse clone 24516, purified immunoglobulin, lyophilized powder

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Anti-Insulin-like Growth Factor-I Antibody, clone M23

Gene Information

mouse ... Igf1(16000)

Gene Information

human ... IGFBP1(3484)

Gene Information

human ... IL4(3565)

Gene Information

human ... IGF1(3479)

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

-

species reactivity

mouse

species reactivity

human

species reactivity

human

species reactivity

human

clone

126002, monoclonal

clone

33627.11, monoclonal

clone

24516, monoclonal

clone

M23, monoclonal

biological source

hamster

biological source

mouse

biological source

mouse

biological source

mouse

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

antibody form

affinity purified immunoglobulin

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Storage Class

13 - Non Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
MKCW0293
MKCG8144
MKCB2794V
MKBT2940V
098K0548

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Related Content

Data Sheet - I9409

Instructions

J Dupont et al.
Hormone research, 55 Suppl 2, 22-26 (2001-10-31)
The insulin receptor (IR) and the insulin-like growth factor I receptor (IGF-IR) belong to the same subfamily of receptor tyrosine kinases with two extracellular alpha-subunits and two transmembrane beta-subunits. They share a high similarity of structure and intracellular signalling events.
C J Rosen
Clinical chemistry, 45(8 Pt 2), 1384-1390 (1999-08-03)
The last decade has been characterized by a major investigative thrust into the physiology of two unique but ubiquitous peptides, insulin-like growth factor (IGF)-I and IGF-II. The regulatory systems that control the tissue bioactivity of the IGFs have been delineated
Ettore Capoluongo
The American journal of pathology, 178(1), 26-31 (2011-01-13)
Insulin and insulin-like growth factors (IGFs) are important regulators of energy metabolism and growth. Several findings have outlined an important role played by this family of molecules in both tumor maintenance and development. Despite the established contribution of the IGF

Global Trade Item Number

SKUGTIN
I9409-500UG04061832714868

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