Product H7779, Retinoic acid p-hydroxyanilide, can be dissolved in DMSO (25 mg/ml) and ethanol (25 mg/ml).
H7779
Retinoic acid p-hydroxyanilide
≥95%
Synonym(s):
4-HPR, Fenretinide, N-(4-Hydroxyphenyl)retinamide
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About This Item
Empirical Formula (Hill Notation):
C26H33NO2
CAS Number:
Molecular Weight:
391.55
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352106
MDL number:
Assay:
≥95%
Form:
powder
Pricing and availability is not currently available.
biological source
synthetic (organic)
Quality Segment
assay
≥95%
form
powder
color
yellow to yellow-orange
storage temp.
−20°C
SMILES string
CC1=C(\C=C\C(C)=C\C=C\C(C)=C\C(=O)Nc2ccc(O)cc2)C(C)(C)CCC1
InChI
1S/C26H33NO2/c1-19(11-16-24-21(3)10-7-17-26(24,4)5)8-6-9-20(2)18-25(29)27-22-12-14-23(28)15-13-22/h6,8-9,11-16,18,28H,7,10,17H2,1-5H3,(H,27,29)/b9-6+,16-11+,19-8+,20-18+
InChI key
AKJHMTWEGVYYSE-FXILSDISSA-N
General description
Retinoic acid p-hydroxyanilide is a synthetic analog of retinoid.
Application
Biochem/physiol Actions
Retinoic acid p-hydroxyanilide, also called fenretinide, increases reactive oxygen species, activates caspases and induces apoptosis. It also inhibits dihydroceramide desaturase, leading to a decrease in ceramide biosynthesis.[1] Fenretinide may elicit anticancer activity in cultured human breast cancer cells.[1] It acts as an insulin antagonist and may be useful in treating insulin resistance.[1] Fenretinide or 4-HPR has chemotherapeutic potential and is cytotoxic to retinoic acid-resistant cancers.[2]
Vitamin A acid analogue with antiproliferative activity; induces apoptosis in malignant hemopoietic cell lines.
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This Item | |||
|---|---|---|---|
| form powder | form powder | form (Powder or Crystal with Lumps) | form (Powder or Powder with Lumps) |
| assay ≥95% | assay ≥98% (HPLC) | assay ≥95.0% (HPLC) | assay ≥97.5% (HPLC) |
| Quality Level 200 | Quality Level 200 | Quality Level 100 | Quality Level 200 |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| color yellow to yellow-orange | color yellow | color yellow to dark yellow | color faint yellow to very dark yellow |
| biological source synthetic (organic) | biological source synthetic (organic) | biological source synthetic | biological source synthetic |
signalword
Danger
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
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In what solvents can product H7779, Retinoic acid p-hydroxyanilide, be dissolved?
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What is the Department of Transportation shipping information for this product?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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How can one store a solution of product H7779, Retinoic acid p-hydroxyanilide?
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A solution of product H7779, Retinoic acid p-hydroxyanilide, can be aliquoted and stored at -20°C for up to 3 months. Solutions should be protect from light.
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