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L-Aspartic acid

Name: <SC>L</SC>-Aspartic acid
Brand: SIGMA

≥99% (HPLC), BioXtra

Synonym(s):

(S)-(+)-Aminosuccinic acid, (S)-Aminobutanedioic acid

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About This Item

Linear Formula:

HO₂CCH₂CH(NH₂)CO₂H

CAS Number:

56-84-8

Molecular Weight:

133.10

NACRES:

NA.26

PubChem Substance ID:

24891385

eCl@ss:

32160406

UNSPSC Code:

12352209

EC Number:

200-291-6

MDL number:

MFCD00002616

Beilstein/REAXYS Number:

1723530

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Properties

Product Name

L-Aspartic acid, BioXtra, ≥99% (HPLC)

product line

BioXtra

Quality Level

200

assay

≥99% (HPLC)

form

powder

impurities

≤0.0005% Phosphorus (P), ≤0.1% Insoluble matter

ign. residue

≤0.1%

color

white to off-white

mp

>300 °C (dec.) (lit.)

solubility

1 M HCl: 0.5 M, clear, colorless

anion traces

chloride (Cl^-): ≤0.05%, sulfate (SO₄^2-): ≤0.05%

cation traces

Al: ≤0.0005%, Ca: ≤0.001%, Cu: ≤0.0005%, Fe: ≤0.0005%, K: ≤0.005%, Mg: ≤0.0005%, NH₄⁺: ≤0.05%, Na: ≤0.005%, Pb: ≤0.001%, Zn: ≤0.0005%

SMILES string

N[C@@H](CC(O)=O)C(O)=O

InChI

1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/t2-/m0/s1

InChI key

CKLJMWTZIZZHCS-REOHCLBHSA-N

Gene Information

human ... CA1(759), CA2(760)
rat ... Grin2a(24409)

Description

Application

Metabolomics Analysis Identifies Differential Metabolites as Biomarkers for Acute Myocardial Infarction.: Research identifies key metabolites, including L-Aspartic acid, involved in the metabolic pathways affected during acute myocardial infarction. This study enhances the understanding of biochemical changes during heart attacks, potentially leading to better diagnostic markers (Zhou et al., 2024).

Biochem/physiol Actions

L-Aspartic acid is a natural proteinogenic amino acid that may be used in the formulation of cell culture media and in protein and polypeptide synthesis systems and procedures. L-Aspartic acid, an NMDA receptor agonist and non-specific glutamate receptor agonist, is used to differentiate and study the mechanisms of NMDA receptors.

Principal neurotransmitter for fast synaptic excitation.

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This Item	A7219	11189	51572
Sigma-Aldrich A8949 L-Aspartic acid	Sigma-Aldrich A7219 L-Aspartic acid	Sigma-Aldrich 11189 L-Aspartic acid	Supelco 51572 L-Aspartic acid
form powder	form powder	form powder or crystals	form -
assay ≥99% (HPLC)	assay 98.5-101.0%	assay ≥99.5% (T)	assay -
product line BioXtra	product line -	product line BioUltra	product line TraceCERT^®
solubility 1 M HCl: 0.5 M, clear, colorless	solubility 1 M HCl: 100 mg/mL	solubility 1 M HCl: 0.5 M at 20 °C, clear, colorless	solubility -
color white to off-white	color white to off-white	color white	color -
cation traces Al: ≤0.0005%, Cu: ≤0.0005%, K: ≤0.005%, NH₄⁺: ≤0.05%, Pb: ≤0.001%, Ca: ≤0.001%, Mg: ≤0.0005%, Zn: ≤0.0005%, Fe: ≤0.0005%, Na: ≤0.005%	cation traces -	cation traces Al: ≤5 mg/kg, As: ≤0.1 mg/kg, Ba: ≤5 mg/kg, Bi: ≤5 mg/kg, Ca: ≤10 mg/kg, Cd: ≤5 mg/kg, Co: ≤5 mg/kg, Cr: ≤5 mg/kg, Cu: ≤5 mg/kg, Fe: ≤5 mg/kg, K: ≤50 mg/kg, Li: ≤5 mg/kg, Mg: ≤5 mg/kg, Mn: ≤5 mg/kg, Mo: ≤5 mg/kg, NH₄⁺: ≤200 mg/kg, Na: ≤100 mg/kg, Ni: ≤5 mg/kg, Pb: ≤5 mg/kg, Sr: ≤5 mg/kg, Zn: ≤5 mg/kg	cation traces -

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Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Mapping Metabolic Events in the Cancer Cell Cycle Reveals Arginine Catabolism in the Committed SG2M Phase.

Irena Roci et al.

Cell reports, 26(7), 1691-1700 (2019-02-14)

Alterations in cell-cycle regulation and cellular metabolism are associated with cancer transformation, and enzymes active in the committed cell-cycle phase may represent vulnerabilities of cancer cells. Here, we map metabolic events in the G1 and SG2M phases by combining cell

Stellate Cells, Hepatocytes, and Endothelial Cells Imprint the Kupffer Cell Identity on Monocytes Colonizing the Liver Macrophage Niche.

Johnny Bonnardel et al.

Immunity, 51(4), 638-654 (2019-09-29)

Macrophages are strongly adapted to their tissue of residence. Yet, little is known about the cell-cell interactions that imprint the tissue-specific identities of macrophages in their respective niches. Using conditional depletion of liver Kupffer cells, we traced the developmental stages

Unsynchronised subunit motion in single trimeric sodium-coupled aspartate transporters.

Guus B Erkens et al.

Nature, 502(7469), 119-123 (2013-10-05)

Excitatory amino acid transporters (EAATs) are secondary transport proteins that mediate the uptake of glutamate and other amino acids. EAATs fulfil an important role in neuronal signal transmission by clearing the excitatory neurotransmitters from the synaptic cleft after depolarization of

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Global Trade Item Number

SKU	GTIN
A8949-100G	04061833400975
A8949-25G	04061833400999
A8949-10MG	04061833617052
A8949-1G	04061833400982

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