Z2626

Zaragozic acid A trisodium salt

from microbial, ≥95% (HPLC), lyophilized powder, squalene synthase inhibitor

• Sinónimos: L-694,599, Squalestatin
• Fórmula empírica (notación de Hill): C₃₅H₄₃O₁₄Na₃
• Número de CAS: 144541-82-2
• Peso molecular: 756.68
• Número MDL: MFCD03788025
• Código UNSPSC: 12352106
• NACRES: NA.77

Propiedades

• Nombre del producto: Zaragozic acid A trisodium salt, ≥95% (HPLC), microbial
• origen biológico: microbial
• Nivel de calidad: 200
• Ensayo: ≥95% (HPLC)
• Formulario: lyophilized powder
• solubilidad: DMSO: 9.80-10.20 mg/mL, clear, colorless to faintly yellow
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C

Descripción

Aplicación

Zaragozic acid A trisodium salt has been used as:

• a component of serum-free medium for human embryonic kidney cells in a wound scratch assay to test its effect on wound healing[1]
• a farnesyl-diphosphate farnesyltransferase 1 (FDFT1) or squalene synthase inhibitor in stromal cells[2]
• a cholesterol synthesis inhibitor in T cells[3]

Acciones bioquímicas o fisiológicas

Potent inhibitor, in vivo and in vitro, of mammalian, fungal and Saccharomyces cervisiae squalene synthase. Squalene synthase is the first committed enzyme in sterol synthesis, catalyzing the reductive condensation of farnesyl pyrophosphate to form squalene. As a squalene synthase inhibitor, zaragozic acid produces lower plasma cholesterol levels in primates. Treatment of rats with zaragozic acid A caused an increase in hepatic low density lipoprotein (LDL) receptor mRNA levels.

Información legal

Manufactured and sold under a restricted license from Merck & Co., Inc., Kenilworth, NJ, U.S.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)