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Documentos

79849

Sigma-Aldrich

(±)-Mevalonic acid 5-phosphate lithium salt hydrate

95% (TLC)

Sinónimos:

(±)-MVAP-Li, rac-5-Phosphomevalonate lithium salt

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About This Item

Fórmula empírica (notación de Hill):
C6H13O7P · xLi+ · yH2O
Peso molecular:
228.14 (free acid basis)
UNSPSC Code:
12352204
PubChem Substance ID:
329768653
NACRES:
NA.32

assay

95% (TLC)

form

powder or crystals

relevant disease(s)

Alzheimer′s disease; autoimmune diseases

storage temp.

2-8°C

SMILES string

OC(CC(C)(O)CCOP(O)(O)=O)=O.[H]O[H].[Li+]

InChI

1S/C6H13O7P.3Li.H2O/c1-6(9,4-5(7)8)2-3-13-14(10,11)12;;;;/h9H,2-4H2,1H3,(H,7,8)(H2,10,11,12);;;;1H2/q;3*+1;/p-3

InChI key

VYTYNAKRCDFACM-UHFFFAOYSA-K

Categorías relacionadas

Biochem/physiol Actions

Metabolite of the mevalonate pathway, which plays a key role in the biosynthesis of sterols, dolichol, heme and ubiquinone. Of interest for research in the disease areas oncology, autoimmune diseases, artherosclerosis and Alzheimer disease, as well as for inherited deficiencies of mevalonate kinase.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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D N Skilleter et al.
The Biochemical journal, 124(2), 407-417 (1971-09-01)
1. Phosphomevalonate kinase and 5-pyrophosphomevalonate decarboxylase have been purified from the freeze-dried latex serum of the commercial rubber tree Hevea brasiliensis. 2. The phosphomevalonate kinase was acid- and heat-labile and required the presence of a thiol to maintain activity. 3.
Li Gong et al.
Cell death & disease, 10(4), 327-327 (2019-04-13)
The mevalonate pathway is known for the synthesis of cholesterol, but recent studies have reported that it also controls Hippo signaling, which is critical for the regulation of organ size and tumorigenesis. Here, we discover that the suppression of the
John L Andreassi et al.
Biochemistry, 48(27), 6461-6468 (2009-06-03)
The galacto-, homoserine-, mevalonate-, phosphomevalonate-kinase (GHMP) superfamily encompases a wide-range of protein function. Three members of the family (mevalonate kinase, phosphomevalonate kinase, and diphosphomevalonate decarboxylase) comprise the mevalonate pathway found in S. pneumoniae and other organisms. We have determined the
Inhibition of hepatic cholesterol biosynthesis by 3,5-dihydroxy-3,4,4-trimethylvaleric acid and its site of action.
F H Hulcher
Archives of biochemistry and biophysics, 146(2), 422-427 (1971-10-01)
Andrew L Olson et al.
Journal of the American Chemical Society, 132(7), 2102-2103 (2010-02-02)
Phosphomevalonate kinase (PMK) catalyzes phosphoryl transfer from adenosine triphosphate (ATP) to mevalonate 5-phosphate (M5P) on the pathway for synthesizing cholesterol and other isoprenoids. To permit this reaction, its substrates must be brought proximal, which would result in a significant and
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