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MilliporeSigma
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Documentos

T6069

Sigma-Aldrich

Thio-TEPA

Sinónimos:

N,N′,N″-Triethylenethiophosphoramide, Thio-Tep, Thiofozil, Thiotef, Tio-tef, Tiofosfamid, Tiofosyl, Tiofozil, Tris(aziridinyl)phosphine sulfide

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About This Item

Fórmula empírica (notación de Hill):
C6H12N3PS
Número de CAS:
52-24-4
Peso molecular:
189.22
EC Number:
200-135-7
MDL number:
MFCD00145452
UNSPSC Code:
51102829
PubChem Substance ID:
24900346
NACRES:
NA.85

form

solid

storage condition

(Keep container tightly closed in a dry and well-ventilated place.)

color

white

antibiotic activity spectrum

neoplastics

mode of action

DNA synthesis | interferes

storage temp.

2-8°C

SMILES string

S=P(N1CC1)(N2CC2)N3CC3

InChI

1S/C6H12N3PS/c11-10(7-1-2-7,8-3-4-8)9-5-6-9/h1-6H2

InChI key

FOCVUCIESVLUNU-UHFFFAOYSA-N

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Categorías relacionadas

General description

Chemical structure: aziridine

Application

A polyfunctional alkylating agent

Biochem/physiol Actions

The unstable nitrogen-carbon groups alkylate with DNA which causes irreversible DNA damage. They stop tumor growth by crosslinking guanine nucleobases in DNA double-helix strands, directly attacking DNA. The DNA strands are unable to uncoil and separate which halts cell division.

Analysis Note

Solubility - freely soluble in water , in chloroform and in ethanol (96%)

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

hcodes

H300,H350

Hazard Classifications

Acute Tox. 2 Oral - Carc. 1B

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk_germany

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Michael P Fay et al.
Statistics in medicine, 31(28), 3760-3772 (2012-07-13)
We consider weighted logrank tests for interval censored data when assessment times may depend on treatment, and for each individual, we only use the two assessment times that bracket the event of interest. It is known that treating finite right
Soo Hyeon Bae et al.
Chemico-biological interactions, 205(1), 11-19 (2013-06-20)
The present study was performed to evaluate the potency and specificity of sibutramine as an inhibitor of the activities of nine human CYP isoforms in liver microsomes. Using a cocktail assay, the effects of sibutramine on specific marker reactions of
Sotirios G Papageorgiou et al.
Hematological oncology, 31(1), 10-17 (2012-05-23)
Central nervous system (CNS) involvement in patients with primary mediastinal large B-cell (PMLBCL) lymphoma is a rare event, occurring in approximately 6% of patients, on the basis of the review of the literature prior to induction of Rituximab. The aim
Ki Woong Sung et al.
Neuro-oncology, 15(3), 352-359 (2012-12-22)
We assessed the feasibility and effectiveness of reduced-dose craniospinal (CS) radiotherapy (RT) followed by tandem high-dose chemotherapy and autologous stem cell transplantation (HDCT/autoSCT) in reducing late adverse effects without jeopardizing survival among children with high-risk medulloblastoma (MB). From October 2005
Samuel A Bobholz et al.
Tomography (Ann Arbor, Mich.), 6(2), 160-169 (2020-06-18)
Magnetic resonance (MR)-derived radiomic features have shown substantial predictive utility in modeling different prognostic factors of glioblastoma and other brain cancers. However, the biological relationship underpinning these predictive models has been largely unstudied, and the generalizability of these models had
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