SML0389

PF-514273

≥98% (HPLC)

• Sinónimos: 2-(2-Chlorophenyl)-3-(4-chlorophenyl)-7-(2,2-difluoropropyl)-6,7-dihydro-2H-pyrazolo[3,4-f][1,4]oxazepin-8(5H)-one
• Fórmula empírica (notación de Hill): C₂₁H₁₇Cl₂F₂N₃O₂
• Número de CAS: 851728-60-4
• Peso molecular: 452.28
• MDL number: MFCD12032112
• UNSPSC Code: 12352202
• PubChem Substance ID: 329825387
• NACRES: NA.77

Propiedades

• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: >5 mg/mL (warmed)
• storage temp.: −20°C
• SMILES string: CC(F)(F)CN1CCOc2c(nn(-c3ccccc3Cl)c2-c4ccc(Cl)cc4)C1=O
• InChI: 1S/C21H17Cl2F2N3O2/c1-21(24,25)12-27-10-11-30-19-17(20(27)29)26-28(16-5-3-2-4-15(16)23)18(19)13-6-8-14(22)9-7-13/h2-9H,10-12H2,1H3
• InChI key: FJMQJSUOOGOWBD-UHFFFAOYSA-N

Descripción

Biochem/physiol Actions

PF-514273 is a highly selective CB1 antagonist. The Ki for binding to CB1 and CB2 receptors is 1 nM and 10 mM, respectively. PF-514273 inhibits food intake and weight gain in rodents.

Features and Benefits

This compound is featured on the Cannabinoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable