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SML0045

Sigma-Aldrich

Salvianolic acid A hydrate

≥98% (HPLC)

Sinónimos:

Dan phenolic acid A hydrate

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About This Item

Fórmula empírica (notación de Hill):
C26H22O10 · xH2O
Número de CAS:
96574-01-5
Peso molecular:
494.45 (anhydrous basis)
Número MDL:
MFCD20527310
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
329825115
NACRES:
NA.77

Ensayo

≥98% (HPLC)

Formulario

powder

color

yellow

solubilidad

H2O: ≥19 mg/mL

Condiciones de envío

wet ice

temp. de almacenamiento

−20°C

cadena SMILES

O.OC(=O)[C@@H](Cc1ccc(O)c(O)c1)OC(=O)\C=C\c2ccc(O)c(O)c2\C=C\c3ccc(O)c(O)c3

InChI

1S/C26H22O10.H2O/c27-18-7-2-14(11-21(18)30)1-6-17-16(4-9-20(29)25(17)33)5-10-24(32)36-23(26(34)35)13-15-3-8-19(28)22(31)12-15;/h1-12,23,27-31,33H,13H2,(H,34,35);1H2/b6-1+,10-5+;/t23-;/m1./s1

Clave InChI

XFUSRNNWIRPEDG-FYLUTCCGSA-N

Aplicación

Salvianolic acid A hydrate may be used in cell signaling studies.
Salvianolic acid A hydrate has been used as rosmarinic acid derivative for the inhibition of DNA polymerase e in human cell lines.[1]

Acciones bioquímicas o fisiológicas

Cell protective antioxidant
Salvianolic acid A acts as scavengers of reactive oxygen species, reduces the adherence of leukocytes to endothelial cells, inhibits matrix metalloproteinases and inflammation.[2] It has cardioprotective effects as it suppresses apoptosis, reduces lipid peroxidation in damaged cardiac tissue and decreases the leakage of lactic acid dehydrogenase.[2][3]
Salvianolic acid A is cell protective antioxidant originally isolated from Salvia. It has been found to attenuate PDGF-induced ROS formation in hepatic stellate cells and protected against isoproterenol-induced myocardial damage in rats.

Código de clase de almacenamiento

13 - Non Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
061M4744V

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Tanshinone I ≥98% (HPLC)

Sigma-Aldrich

T5330

Tanshinone I

Rosmarinic acid ≥98% (HPLC), from Rosemarinus officinalis L.

Sigma-Aldrich

R4033

Rosmarinic acid

Rosmarinic acid primary reference standard

00390580

Rosmarinic acid

Heng-ai Zhang et al.
Biochemical and biophysical research communications, 421(3), 479-483 (2012-04-21)
Salvianolic acid A (Sal A) is a polyphenol extracted from the root of the Salvia miltiorrhiza bunge. Hydrogen peroxide (H(2)O(2)) is a major reactive oxygen species (ROS), which has been implicated in stroke and other neurodegenerative diseases, including Alzheimer's disease
Baohong Jiang et al.
PloS one, 8(3), e59621-e59621 (2013-03-28)
Cardiac fibrosis is a deleterious consequence of hypertension which may further advance to heart failure and increased matrix metalloproteinase-9 (MMP-9) contributes to the underlying mechanism. Therefore, new therapeutic strategies to attenuate the effects of MMP-9 are urgently needed. In the
Xiao-Juan Lai et al.
Fitoterapia, 82(6), 883-888 (2011-05-18)
Salviae miltiorrhizae is one of the most commonly used herbal plants in the treatment of numerous ailments including cardiovascular diseases for hundreds of years. According to the theory of traditional Chinese herbal medicine, S. miltiorrhizae is always used in combination
Jing Wang et al.
Folia neuropathologica, 59(1), 50-66 (2021-05-11)
More than 50 million people are affected by traumatic brain injury (TBI) each year around the world, and nearly half of the population worldwide will have one or more TBI(s) in their lifetime. And in 2017, more than 1.39 billion
Li Zhang et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 36(19), 2603-2609 (2012-01-17)
Salvianolic acid A is a water-soluble component from Danshen, which is frequently used in traditional Chinese medicine. High performance liquid chromatography was often used to analyze content of salvianolic acid A. The yield of salvianolic acid A increased by the
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