Stock solutions of this product may be stored at -20 °C for up to three months in aliquots. Stability data has not been collected for stock solutions at 2-8°C. This product does not need to be protected from light as it is not light-sensitive. Please see the link below to review the product datasheet for additional information:
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/385/900/c9911pis.pdf
C9911
(S)-(+)-Camptothecin
≥90% (HPLC), powder, DNA topoisomerase I inhibitor
Sinónimos:
(S)-4-Ethyl-4-hydroxy-1H-pyrano-[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
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| A ustedes/SKU | Disponibilidad | Precio |
|---|---|---|
100 mg | Envío estimado HOYdesdeMILWAUKEE | $144.00 |
250 mg | Envío estimado HOYdesdeMILWAUKEE | $316.00 |
1 g | Envío estimado HOYdesdeSAINT LOUIS | $890.00 |
Acerca de este artículo
Fórmula empírica (notación de Hill):
C20H16N2O4
Número CAS:
Peso molecular:
348.35
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Beilstein/REAXYS Number:
631069
Assay:
≥90% (HPLC)
Form:
powder
Servicio técnico
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Permítanos ayudarleNombre del producto
(S)-(+)-Camptothecin, ≥90% (HPLC), powder
Quality Segment
assay
≥90% (HPLC)
form
powder
mp
260 °C (dec.) (lit.)
solubility
chloroform/methanol (4:1): 5 mg/mL
antibiotic activity spectrum
neoplastics
mode of action
DNA synthesis | interferes, enzyme | inhibits
storage temp.
2-8°C
SMILES string
CC[C@@]1(O)C(=O)OCC2=C1C=C3N(Cc4cc5ccccc5nc34)C2=O
InChI
1S/C20H16N2O4/c1-2-20(25)14-8-16-17-12(7-11-5-3-4-6-15(11)21-17)9-22(16)18(23)13(14)10-26-19(20)24/h3-8,25H,2,9-10H2,1H3/t20-/m0/s1
InChI key
VSJKWCGYPAHWDS-FQEVSTJZSA-N
Gene Information
human ... TOP1(7150)
mouse ... Prkca(18750)
rat ... Sstr2(54305)
Biochem/physiol Actions
(S)-(+)-Camptothecin binds irreversibly to the DNA-topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA. The enzyme complex is ubiquinated and destroyed by the 26S proteasome, thus depleting cellular topoisomerase I. Blocks the cell cycle in S-phase at low does and induces apoptosis in a large number of normal and tumor cell lines by cell cycle-dependent and cell cycle-independent processes.
Features and Benefits
This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
Other Notes
20S isomer
1 of 1
Este artículo | |||
|---|---|---|---|
| assay ≥90% (HPLC) | assay ≥95% (HPLC) | assay ≥97% (HPLC) | assay ≥98% (HPLC) |
| form powder | form solid | form powder | form powder |
| Quality Level 200 | Quality Level 100 | Quality Level - | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. -10 to -25°C |
| solubility chloroform/methanol (4:1): 5 mg/mL | solubility DMSO: 10 mg/mL, methanol: 40 mg/mL | solubility DMSO: 50 mg/mL | solubility DMSO: 2 mg/mL, clear (Warmed) |
| mp 260 °C (dec.) (lit.) | mp - | mp - | mp - |
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Muta. 1B
Clase de almacenamiento
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
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How long can (S)-(+)-camptothecin C9911 be stored at 2-8°C? Should it be protected from light? Is it light-sensitive?
1 answer-
Helpful?
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What is the extinction coefficient of Product C9911, (S)-(+)-Camptothecin?
1 answer-
The millimolar extinction coefficients (EmM) at various wavelengths are 37.3 (220 nm); 29.2 (254 nm); 4.9 (290 nm); 19.9 (370 nm).
Helpful?
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What is Product C9911, (S)-(+)-Camptothecin, soluble in?
1 answer-
This product is soluble in DMSO (10 mg/mL). At higher concentrations, heating is required for the product to dissolve completely (approximately 10 minutes at 95°C), but some precipitation occurs upon cooling to room temperature. It is also soluble in 1 N NaOH (50 mg/mL) and methanol (50 mg/mL).
Helpful?
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
Helpful?
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What is the solution stability of Product C9911, (S)-(+)-Camptothecin?
1 answer-
Stock solutions of camptothecin in DMSO can be stored at -20°C for up to 3 months.
Helpful?
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