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D0400000

Deoxycorticosterone acetate

European Pharmacopoeia (EP) Reference Standard

Sinónimos:

Deoxycorticosterone acetate, 11-Deoxycorticosterone acetate, 21-Acetoxy-4-pregnene-3,20-dione, 21-Acetoxyprogesterone, 21-Hydroxy-4-pregnene-3,20-dione 21-acetate, 21-Hydroxyprogesterone 21-acetate, 4-Pregnen-21-ol-3,20-dione 21-acetate, Cortexone acetate, DOC acetate

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100 MG
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100 MG
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About This Item

Fórmula empírica (notación de Hill):
C23H32O4
Número de CAS:
56-47-3
Peso molecular:
372.50
Beilstein:
2570798
Número MDL:
MFCD00003660
Código UNSPSC:
41116107
ID de la sustancia en PubChem:
329798604
NACRES:
NA.24

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grado

pharmaceutical primary standard

familia API

desoxycortone

fabricante / nombre comercial

EDQM

aplicaciones

pharmaceutical (small molecule)

Formato

neat

cadena SMILES

[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@]4(C)[C@]([H])(CC[C@@]24[H])C(=O)COC(C)=O

InChI

1S/C23H32O4/c1-14(24)27-13-21(26)20-7-6-18-17-5-4-15-12-16(25)8-10-22(15,2)19(17)9-11-23(18,20)3/h12,17-20H,4-11,13H2,1-3H3/t17-,18-,19-,20+,22-,23-/m0/s1

Clave InChI

VPGRYOFKCNULNK-ACXQXYJUSA-N

Información sobre el gen

human ... NR3C2(4306)

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Descripción general

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicación

Desoxycortone acetate EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Envase

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Otras notas

Sales restrictions may apply.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Carrie A Northcott et al.
Experimental biology and medicine (Maywood, N.J.), 237(1), 99-110 (2012-01-10)
One challenge in understanding the polygenic disease of hypertension is elucidating the genes involved and defining responses to environmental factors. Many studies focus on animal models of hypertension; however, this does not necessarily extrapolate to humans. Current technology and cost
Saad Lahlou et al.
Fundamental & clinical pharmacology, 17(3), 323-330 (2003-06-14)
The present study investigated the hypotensive responses to intravenous (i.v.) treatment with the essential oil of Alpinia zerumbet (EOAZ) and its main constituent, terpinen-4-ol (Trp-4-ol), in the experimental model of deoxycorticosterone-acetate (DOCA)-salt hypertensive rat. In both DOCA-salt hypertensive and uninephrectomized
Riccardo Candido et al.
American journal of hypertension, 18(6), 844-850 (2005-06-01)
The aim of the present study was to compare glomerular permeability alterations associated with experimental hypertension models known to have different effects on the circulating renin-angiotensin system (RAS). Five groups, 10 animals each, were studied. One group served as a
J P Davis et al.
Clinical science (London, England : 1979), 81(1), 73-78 (1991-07-01)
1. Hypertension was induced in male Sprague-Dawley rats by left unilateral nephrectomy and deoxycorticosterone acetate--salt administration. After 5 weeks, arterial systolic blood pressure was significantly elevated in these animals (191.5 +/- 6.0 mmHg, mean +/- SD, n = 17) compared
Ibrahim F Benter et al.
Vascular pharmacology, 51(2-3), 101-109 (2009-05-05)
Renal dysfunction is a major cause of morbidity and mortality in patients with hypertension. In an attempt to understand the molecular mechanisms leading to renal dysfunction and in particular that of epidermal growth factor receptor (EGFR) and RasGTPase signaling, we
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