D7000

Deoxycorticosterone acetate

• Sinónimos: 11-Deoxycorticosterone acetate, 21-Acetoxy-4-pregnene-3,20-dione, 21-Acetoxyprogesterone, 21-Hydroxy-4-pregnene-3,20-dione 21-acetate, 21-Hydroxyprogesterone 21-acetate, 4-Pregnen-21-ol-3,20-dione 21-acetate, Cortexone acetate, DOC acetate
• Fórmula empírica (notación de Hill): C₂₃H₃₂O₄
• Número de CAS: 56-47-3
• Peso molecular: 372.50
• Beilstein: 2570798
• Número CE: 200-275-9
• Número MDL: MFCD00003660
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 24894065
• NACRES: NA.77

Propiedades

• origen biológico: synthetic (organic)
• esterilidad: non-sterile
• Ensayo: ≥98% (HPLC)
• Formulario: powder
• solubilidad: H₂O: insoluble; acetone: soluble (1 in 30); alcohol: soluble (1 in 50); chloroform: freely soluble; dioxane: slightly soluble; vegetable oils: slightly soluble
• Condiciones de envío: ambient
• temp. de almacenamiento: room temp
• cadena SMILES: [H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@]4(C)[C@]([H])(CC[C@@]24[H])C(=O)COC(C)=O
• InChI: 1S/C23H32O4/c1-14(24)27-13-21(26)20-7-6-18-17-5-4-15-12-16(25)8-10-22(15,2)19(17)9-11-23(18,20)3/h12,17-20H,4-11,13H2,1-3H3/t17-,18-,19-,20+,22-,23-/m0/s1
• Clave InChI: VPGRYOFKCNULNK-ACXQXYJUSA-N
• Información sobre el gen: human ... NR3C2(4306)

Descripción

Descripción general

Deoxycorticosterone acetate is an endogenous neurosteroid found in brain and peripheral circulation, which is produced by progesterone. It is both a mineralocorticoid and a glucocorticoid. It is used to treat adrenocortical insufficiency or Addison′s disease. Deoxycorticosterone acetate improves insulin sensitivity. It acts as a precursor to glucocorticoid corticosterone and the GABAergic neuroactive steroid (3α,5α)-3,21-dihydroxypregnan-20-one.

Aplicación

Deoxycorticosterone acetate has been used to induce hypertensive pregnancy. It has also been used to investigate the effect of low epicatechin dosing on the cardiovascular function of deoxycorticosterone acetate (DOCA)-salt hypertensive rats.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)