539690

Protein Synthesis Initiation Inhibitor, NSC 119889

The Protein Synthesis Initiation Inhibitor, NSC 119889 blocks 5′-mediated/cap-dependent initiation of protein synthesis. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

• Sinónimos: Protein Synthesis Initiation Inhibitor, NSC 119889, 3,4,5,6-Tetrabromofluorescein
• Fórmula empírica (notación de Hill): C₂₀H₈Br₄O₅
• Peso molecular: 647.89
• Código UNSPSC: 12352202
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥95% (HPLC)
• Formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; protect from light
• color: light brown
• solubilidad: DMSO: 200 mg/mL; methanol: soluble
• Condiciones de envío: ambient
• temp. de almacenamiento: 2-8°C

Descripción

Descripción general

A cell-permeable, xanthenyl compound that prevents mRNA-ribosome interaction and inhibits 5’-mediated/cap-dependent initiation of protein synthesis (>95% inhibition at 50 µM in in vitro translation assays using Krebs, rabbit reticulocyte, or E. coli S30 extract).

Acciones bioquímicas o fisiológicas

Cell permeable: yes

Primary Target
human arginine methyl transferase

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 1.41 µM against human arginine methyl transferase

Advertencia

Toxicity: Irritant (B)

Reconstitución

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Otras notas

Novac, O., et al. 2004. Nucleic Acids Res.32, 902.
Tan, Y.J., et al. 2003. J. Cancer Res. Clin. Oncol.129, 437.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable