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T3309

Sigma-Aldrich

Transferrin human

≥98%

Synonym(s):

Siderophilin, partially saturated

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100 MG
$187.00
500 MG
$586.18
1 G
$1,020.00

About This Item

CAS Number:
11096-37-0
EC Number:
234-318-8
MDL number:
MFCD00132442
UNSPSC Code:
12352202
NACRES:
NA.61

$187.00

In StockDetails

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biological source

human

Quality Level

200

assay

≥98%

form

powder

Iron content

300-600 ppm

technique(s)

cell culture | stem cell: suitable

impurities

≤1.0 EU/mg endotoxin

UniProt accession no.

P02787

storage temp.

2-8°C

Gene Information

human ... TF(7018)

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General description

Transferrin is an 80 kDa serum glycoprotein,[1] which has an half-life of 8 to 10 days.[2] The gene is located on human chromosome 3q22.1.[3] Transferrin is expressed in hepatocytes.[4]

Application

Transferrin has been used:
  • in isolation of epidermal stem cells and cell expansion[5]
  • to study the effect of compound treatment on transferrin uptake[6]
  • for transferrin uptake and confocal imaging[7]

Biochem/physiol Actions

Transferrin facilitates the transfer of iron to erythron and peripheral tissues.[8] Mutations in this gene is associated with atransferrinemia.[9][10] Transferrin is required for fetal development.[11] It is non immunogenic and transferrin-conjugated drugs inhibits cardiotoxicity and drug resistance.[12]
Transferrin was shown to promote the proliferation of human lymphocytes. This effect is directly proportional to the level of iron present. [13]

Analysis Note

Purity by agarose electrophoresis.

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

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Certificates of Analysis (COA)

Lot/Batch Number
BCCK3472
BCCJ7138
BCCF8976
BCCF3212
BCCD4179

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TFRC (transferrin receptor (p90, CD71))
Dorak MT
Atlas of Genetics and Cytogenetics in Oncology and Haematology (2009)
Nutritional issues in the patient with diabetes and foot ulcers
LITCHFORD MD
Levin and O'Neal's The Diabetic Foot, 199-217 (2008)
Severe hypochromic microcytic anemia in a patient with congenital atransferrinemia
Shamsian BS, et al.
Pediatric Hematology and Oncology, 26(5), 356-362 (2009)
A Djeha et al.
British journal of haematology, 80(2), 235-241 (1992-02-01)
The effect of different forms of iron and iron-binding proteins on the proliferative response of human lymphocytes to phytohaemagglutinin (PHA) has been studied. Transferrin enhanced proliferation, the effect being proportional to the degree of iron saturation up to 100%, but
Non-invasive in vivo imaging of near infrared-labeled transferrin in breast cancer cells and tumors using fluorescence lifetime FRET
Abe K, et al.
PLoS ONE, 8(11), e80269-e80269 (2013)
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Questions

1–3 of 3 Questions  

  1. HOW IS THIS PROTEIN PRODUCED AND WHAT IS THE REST 2% IMPURITY? THANKS!

    1 answer

    1. This product is prepared by an ammonium sulfate precipitation process followed by a heat treatment and ion exchange chromatography purification. The specific details are considered proprietary. There is no treatment or handling during production that would be expected to cause deglycosylation of the protein. The residual impurities have not been identified. This product is tested for endotoxin and iron. Please see the Sample Certificates of Analysis: https://www.sigmaaldrich.com/certificates/Graphics/COfAInfo/fluka/pdf/PDF746107.pdf

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  2. What is the Department of Transportation shipping information for this product?

    1 answer

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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  3. What is the carbohydrate content of human transferrin?

    1 answer

    1. We have found the information on transferrin in a reference book:The Plasma Proteins, F.W. Putnam, ed, volume 2, chapter 4, Table II.According to the table, Transferrin is 6 percent carbohydrate, citing G.A. Jamieson, J. Biol. Chem. 240(7), 2914-2920 (1965).The table also gives information on the percentage of each type of monosaccharide that is present.

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