SML2630
Intronistat B hydrobromide
≥98% (HPLC)
Synonym(s):
N-(2-(Pyrrolidin-1-yl)ethyl)-2-(3,4,5-trihydroxybenzoyl) benzofuran-5-carboxamide hydrobromide
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About This Item
Empirical Formula (Hill Notation):
C22H22N2O6 · xHBr
Molecular Weight:
410.42 (free base basis)
UNSPSC Code:
51111800
NACRES:
NA.77
Recommended Products
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to dark gray
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Biochem/physiol Actions
Intronistat B is a potent inhibitor of the self-splicing group IIB intron, a mitochondrial RNA tertiary structure necessary for respiration in fungi, yeast and plants, but not found in vertebrates. Intronistat B was found to have antifungal activity comparable to that of amphotericin B in inhibiting growth of the Candida parapsilosis. It did not inhibit spliceosomal processing, group I intron splicing or splicing of group II introns from subclasses other than subclass IIB and was not toxic to human cells.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
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Olga Fedorova et al.
Nature chemical biology, 14(12), 1073-1078 (2018-10-17)
Specific RNA structures control numerous metabolic processes that impact human health, and yet efforts to target RNA structures de novo have been limited. In eukaryotes, the self-splicing group II intron is a mitochondrial RNA tertiary structure that is absent in
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