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Q111

Sigma-Aldrich

(±)-Quinpirole dihydrochloride

powder

Synonym(s):

trans-(±)-4,4a,5,6,7,8,8a,9-Octahydro-5-propyl-1H-pyrazolo[3,4-g]quinoline dihydrochloride, LY-141,865

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50 MG
$267.00

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50 MG
$267.00

About This Item

Empirical Formula (Hill Notation):
C13H21N3 · 2HCl
CAS Number:
Molecular Weight:
292.25
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77

$267.00


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form

powder

color

white

solubility

H2O: 28 mg/mL

storage temp.

−20°C

SMILES string

Cl.Cl.[H][C@]12CCCN(CCC)[C@]1([H])Cc3cn[nH]c3C2

InChI

1S/C13H21N3.2ClH/c1-2-5-16-6-3-4-10-7-12-11(8-13(10)16)9-14-15-12;;/h9-10,13H,2-8H2,1H3,(H,14,15);2*1H/t10-,13-;;/m1../s1

InChI key

GJIGRGIGKHPYTK-OWVUFADGSA-N

Gene Information

human ... DRD2(1813)

Biochem/physiol Actions

D2-like dopamine receptor agonist that possesses some activity at D3 sites.

Legal Information

Manufactured and sold with the permission of Eli Lilly and Company.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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D Eilam et al.
European journal of pharmacology, 161(2-3), 151-157 (1989-02-28)
The effects of the D-2 agonist quinpirole on forward progression, and on vertical and lateral movements, were measured for 2 h in rats injected with either saline, 0.03, 0.125, 0.5 or 8 mg/kg of the drug. Results showed that the
Cristina Cariulo et al.
Biochemical and biophysical research communications, 521(3), 549-554 (2019-11-05)
Huntington's disease (HD) is a progressive neurodegenerative disorder caused by an expansion of a CAG triplet repeat (encoding for a polyglutamine tract) within the first exon of the huntingtin gene. Expression of the mutant huntingtin (mHTT) protein can result in
L J Munro et al.
Brain research, 746(1-2), 231-238 (1997-01-23)
Dopamine (DA) D2 and gamma-aminobutyric acid (GABA)A somatodendritic receptors tonically inhibit mesolimbic projection neurons in the A10 DA cell grouping of the ventral tegmentum. In the present study we determined the contribution of the ventral tegmental area (VTA) to the
Gunnar F Kwakye et al.
Neurotoxicology, 70, 48-61 (2018-11-07)
Huntington's disease (HD) is functionally linked to environmental factors including cigarette use and dyshomeostasis in the levels of metals. Interestingly, one of the most abundant heavy metals in cigarettes is cadmium (Cd), which also accumulates in the striatum and causes
Compounds selective for dopamine receptor subtypes.
Kebabian, et al.
Drug Discovery Today, 2, 333-340 (1997)

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